高压氧对脑梗死患者血浆SOD和CRP的影响及临床意义(1)
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【摘要】 目的 研究高压氧对脑梗死患者血浆SOD和CRP的影响及其临床意义。方法 78例脑梗死患者随机分为高压氧治疗组(HBO组，40例)和临床治疗组(临床组，38例)。临床组给予常规治疗；HBO组给予高压氧及临床常规治疗；21例健康志愿者为健康对照组(对照组)。于治疗前、后检测血清SOD、CRP含量，同时评价两组的治疗效果。结果 HBO组与临床组治疗前的血清SOD、含量与健康组比较，差异有统计学意义(P<0.01)；HBO组治疗后与治疗前比较，血清SOD含量升高及CRP含量下降，差异有统计学意义(P<0.01)；HBO组治疗后血清SOD含量升高、CRP含量降低以及总有效率均较临床组明显(P<0.01)。结论 高压氧治疗可使脑梗死患者血清SOD活性升高，血清CRP水平降低，机体清除自由基的能力增强，从而对脑梗死具有良好疗效。同时提示SOD、CRP的血清含量可用以判断高压氧治疗对脑梗死患者的疗效和预后。
【关键词】 高压氧；脑梗死；超氧化物歧化酶；C反应蛋白
Study of the effect of hyperbaric oxygenation on activities of serum SOD and CRP and its clinical significance in patients with cerebral infarction
NIE Yan-ling. Department of Hyperbaric Oxygenation, The First People’s Hospital of Shangqiu, Henan 476100, China
【Abstract】 Objective To study the effect of hyperbaric oxygenation(HBO)therapy on the activities of serum SOD and CRP of patients with cerebral infarction and its clinical significance. Methods 78 patients with cerebral infarction were randomly divided into hyperbaric oxygen group(HBO Group, 40 cases)and clinical group(38 cases). The clinical group was treated with clinical conventional treatment only. HBO group was treated with HBO combined with clinical conventional treatment. 21 healthy volunteers were assigned to control group. Before and after treatment, the activities of serum SOD and CRP level were measured, and the curative effect were evaluated.Results The pretreatment serum SOD and CRP of the HBO group and clinical group were significantly different from the control group(P<0.01). Compared with the pretreatment and posttreatment serum level of the HBO group, SOD raised, CRP lowered, the difference was significant(P<0.01). Compared with clinical group, SOD raised,CRP lowered and the total cure rate of the HBO group were more significant different(P<0.01). Conclusion HBO therapy raised the activities of SOD and lower the level of CRP in serum of the patients with cerebral infarction, and improved the free radicals scavenging ability in the body ......
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