[摘要] 目的 了解惠州市抗感染药致不良反应发生的特点。方法 对惠州药品不良反应(ADR)工作站2008年收集到的702例抗感染药致ADR报告,利用Excel软件进行分类统计和分析。结果 引起ADR的抗感染药涉及12大类82个品种,其中头孢菌素类居首位,其次为喹诺酮类。给药途径以静脉用药为主(586例,83.48%)。ADR的临床表现主要为皮肤及其附件损害(占53.13%)。结论 加强抗感染药不良反应监测,促进临床安全合理用药。

    [关键词] 药品不良反应;抗感染药;分析

    [中图分类号] R978.1 [文献标识码] A[文章编号] 1673-9701(2009)34-42-03

    Adverse Drug Reaction Induced by Anti-infectives: An Analysis of 702 Cases in 2008

    LI Chuyun1CHEN Meiling1ZHAN Yunli2

    1. Huizhou Municipal Central People’s Hospital,Huizhou 516001, China; 2. Huizhou Municipal Institute for Drug Control, Huizhou 516003,China

    [Abstract] Objective To investigate the characteristics of adverse drug reaction(ADR) in our city. Methods The data of 702 ADR cases induced by anti-infective drugs from ADR workstation in our city in 2008 were classified and analyzed statistically by using Excel software. Results Of the 702 ADR cases,12 categories(82 kinds) of anti-infective drugs were involved and cephalosporins ranked the first followed by quinolones. The intravenous administration(586 cases, 83.48%)was the main route. The main clinical manifestations of ADR included the damage to the skin and its accessories(53.13%). Conclusion ADR monitoring should be strengthened in using anti-infective drugs to promote rational drug use. ......