E-cadherin与Snail在涎腺腺样囊性癌中的表达及意义(1)
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[摘要] 目的 研究E-cadherin与Snail 在人腺样囊性癌(SACC)中的表达及临床意义。方法 用免疫组化的方法检测E-cadherin与Snail在SACC及正常涎腺组织中的表达。结果 (1)与正常涎腺组织相比,E-cadherin在SACC中表达下降,差异有统计学意义(P<0.05),E-cadherin表达与不同组织病理学类型有关,且在发生神经侵犯及远处转移的病例中,E-cadherin表达下降更明显(P<0.05,P<0.01)。(2)Snail在SACC 中表达,且Snail表达与组织病理学类型及生物学行为有关,在实体型及发生神经侵犯及远处转移的病例中,Snail表达明显增加(P<0.001,P<0.05,P<0.05)。(3)在SACC, E- cadherin与Snail的表达呈负相关(r=-0.496,P<0.001)。结论 Snail与E-cadherin的联合检测可作为SACC恶性程度及预后的参考指标。
[关键词] E-cadherin;Snail;腺样囊性癌
[中图分类号] R781.7 [文献标识码] A [文章编号] 1673-9701(2010)04-14-03
Expression of E-cadherin and Snail in Salivary Adenoid Cystic Carcinoma and Its Significance
LI YuwangNAN XinrongLINGHU Qingxi
The First Affiliated Hospital of Shanxi Medical College,Taiyuan 030001,China
[Abstralt] ObjectiveTo study the expression of E-cadherin and Snail in salivary adenoid cystic carcinoma and its significance ......
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