子宫内膜异位症患者血清中VEGF的表达及意义(1)
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[摘要] 目的 检测血管内皮生长因子(Vascular endothelial growth factor,VEGF)在子宫内膜异位症(endometriosis,EMs)患者血清中的表达水平,以探讨其在子宫内膜异位症发病机制中的作用及其与患者痛经的关系。方法 应用酶联免疫吸附法(enzyme-linked immunosobent assay,ELISA)检测48例(I、II期22例,III、IV期26例)EMs患者及40例非EMs患者血清中VEGF的表达水平,分析其与EMs以及患者痛经严重程度的关系。结果 EMs患者血清中VEGF的表达水平明显高于非EMs患者(P<0.05);Ⅲ、Ⅳ期EMs患者血清VEGF的水平高于Ⅰ、Ⅱ期患者(P<0.05);血清中VEGF的表达水平与患者痛经严重程度无明显相关性(P>0.05)。结论 VEGF在EMs患者血清中呈高表达,且与患者病情呈正相关,提示其在EMs的发生、发展中可能具有促进作用;血清中VEGF的水平无法反映痛经的严重程度。
[关键词] 子宫内膜异位症; 血管内皮生长因子; 酶联免疫吸附试验; 痛经
[中图分类号] R711.71[文献标识码] A [文章编号] 1673-9701(2010)05-48-02
Expression of Serum Vascular Endothelial Growth Factor in Endometriosis and Its Significance
LI Fengmei MA Nan LIU Jia
Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China
[Abstract] ObjectiveTo investigate the expression level of serum vascular endothelial growth facter(VEGF)in endometriosis and explore its role in the pathogenesis of endometriosis,and the relationship between the VEGF level and dysmenorrheal ......
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