血流剪切力在动脉粥样硬化中所起的作用(1)
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[摘要] 动脉粥样硬化(atherosclerosis,AS)是严重威胁人类身体健康的疾病,临床资料表明,动脉粥样硬化好发于动脉开口、分叉和弯曲的部位,说明血流动力学在动脉粥样硬化的形成过程中起了重要作用。多项研究表明,不合适的血流剪切力会通过一系列的机制影响血管内皮细胞重构、增殖及凋亡,促进单核/巨噬细胞游走至血管弹力层,形成平滑肌细胞并病理性增殖,促进低密度脂蛋白(LDL)在血管内皮的沉积等等,从而在动脉粥样硬化的发生、发展及演变中起了极其重要的作用。
[关键词] 动脉粥样硬化; 血流剪切力; 基因; 炎症
[中图分类号] R543.5 [文献标识码] A [文章编号] 1673-9701(2010)09-13-03
Role of Blood Flow Shear Stress in Atherosclerosis
LUO Cheng ZHUANG Minghua
Department of Neurosurgery,the First Affiliated Hospital of Medical College of Shantou University,Shantou 515041,China
[Abstract]Atherosclerosis is a dangerous disease to human being. Clinical data show that atherosclerosis is inclined to dwell on the opening position,bifurcate and curve parts of the artery,which indicates that hematodynamics plays an important role in the process of atherosclerosis ......
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