醒脑汤联合纳洛酮对急性重症颅脑外伤患者昏迷评分的影响
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[摘要] 目的 观察盐酸纳洛酮联合醒脑汤在治疗急性重症颅脑外伤患者中的疗效。方法 将96例重症颅脑外伤患者随机分为观察组和对照组各48例，观察组给予醒脑汤和纳洛酮，对照组给予纳洛酮，比较两组疗效差异。结果 两组治疗14d后经GCS预后评分，观察组治愈25例(52.08%)，显效10例(20.83%)，有效9例(18.75%)，与对照组比较，差异有统计学意义(P<0.05)。从第4天开始两组GCS评分、体温、心率、血压和呼吸差异均具有统计学意义(P<0.05)。结论 醒脑汤联合纳洛酮治疗明显缩短了急性重症颅脑外伤患者的意识恢复时间，值得在临床上推广应用。
[关键词] 急性重症颅脑外伤；盐酸纳洛酮；醒脑汤
[中图分类号] R651.1+5[文献标识码] B [文章编号] 1673-9701(2011)21-47-02
Observe the Impact on GCS of Patients with Acute Severe Brain Injury Treated with Refreshing Soup and Naloxone
HUANG Tao
Department of Thoracic Surgery，The Hospital of Traditional Chinese Medicine of Huangyan District in Taizhou City of Zhejiang province，Taizhou 318020，China
[Abstract] Objective To observe the effect of patients with acute severe traumatic brain injury treated by united refreshing soup naloxone. Methods Ninety-six patients with severe traumatic brain injury were randomly divided into observation group and the control group，48 cases in the observation group were given refreshing soup and naloxone，the control group was given naloxone，compared the effect of two groups. Results 14d prognosis of two groups by the GCS score，in the observation group，25 cases were cured(52.08%) ，markly effective 10 cases(20.83%)， effective 9 cases(18.75%)，compared with the control group，the difference was statistically significant (P<0.05). from the 4th day difference of GCS，temperature，heart rate，blood pressure and breathe between two groups were significant(P<0.05). Conclusion Naloxone combined with refreshing soup can significantly reduce severe traumatic brain injury recovery time，it is in the clinical application.
[Key words] Acute severe traumatic brain injury；Naloxone；Refreshing soup
急性重症颅脑外伤是临床常见的危急病症，如果救治不及时，易导致患者死亡或留有伤残等后遗症。相关研究证实，早期应用大剂量的盐酸纳洛酮能明显降低急性颅脑外伤患者的死亡率、使脑神经的功能改善、提高远期生活质量水平，同时具有相当可靠的安全性[1]。我院对2006年10月～2010年10月收治的96例急性重症颅脑外伤患者进行治疗，给予盐酸纳洛酮联合醒脑汤，取得了显著的疗效，现报道如下。
1资料与方法
1.1一般资料
选择2006年10月～2010年10月我院科室收治的96例急性重症颅脑外伤患者，经头颅CT检查确诊有脑外伤史。随机分为两组，观察组48例，其中男32例，女16例；年龄18～60岁，平均(32.4±7.5)岁；格拉斯哥昏迷(GCS)评分为3～5分20例，6～8分28例；其中脑内血肿19例，硬膜外血肿10例，硬膜下血肿6例，深度昏迷8例，中度2例，浅度3例；手术清除血肿33例，保守治疗15例。对照组48例，其中男30例，女18例；年龄19～63岁 ......
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