前列地尔与巴曲酶治疗LEAD的疗效与经济性比较
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[摘要] 目的 比较前列地尔注射液和巴曲酶注射液治疗糖尿病下肢动脉血管病变(lower-extremity arterial disease，LEAD)的疗效和经济性。方法 40例LEAD患者分成前列地尔组和巴曲酶组。巴曲酶组：巴曲酶注射液治疗；前列地尔组：前列地尔注射液治疗。结果 前列地尔组和巴曲酶组的显效率、有效率、改善率及总有效率比较，差异无显著性(P>0.05)。两组左足背动脉内径及血流量、右足背动脉内径及血流量在治疗后均明显改善，差异具有显著性(P<0.01或P<0.05)，但两组间左足背动脉内径及血流量、右足背动脉内径及血流量比较，差异无显著性(P>0.05)。两组不良反应率差异无显著性(P>0.05)。前列地尔组(总费用：2030元)比巴曲酶组(总费用：4350元)经济实惠。结论 前列地尔注射液治疗LEAD疗效可靠，也相对经济实惠。
[关键词] 前列地尔注射液；巴曲酶注射液；糖尿病下肢动脉血管病变
[中图分类号] R587.2 [文献标识码] B [文章编号] 1673-9701(2011)21-84-02
Comparison of Efficacy and Economy between Alprostadil Injection and Batroxobin Injection Treatment of LEAD
YU Xianmei
Department of Medicine，Qujiang District People's Hospital of Quzhou City，in Zhejiang Province, Quzhou 324000，China
[Abstract] Objective Comparison of efficacy and economy between alprostadil injection and batroxobin injection treatment of LEAD. Methods Forty cases of LEAD were divided into alprostadil group and batroxobin group. Batroxobin group：batroxobin injection；Alprostadil Group：alprostadil injection. Results The difference of markedly effective, efficient, improving rate and total effective rate of alprostadil group and batroxobin group was not significant (P>0.05). Diameter and blood flow of the left foot dorsal artery and right foot dorsal artery significantly improved after treatment, the difference was significant (P<0.01or P<0.05), but the difference of the two groups was not statistically significant (P>0.05).The difference of adverse reaction rate of the two groups was not significant (P>0.05). Alprostadil group (total cost：2030 yuan) was cheaper than batroxobin group (total cost：4350 yuan). Conclusion Alprostadil injection treatment of LEAD had good efficacy，and affordable.
[Key words] Alprostadil injection；Batroxobin injection；Lower-extremity arterial disease
糖尿病下肢动脉血管病变(lower-extremity arterial disease，LEAD)是糖尿病患者致残的主要原因之一，目前多使用前列地尔[1]或者巴曲酶[2]治疗LEAD，但本地区两者之间医疗费用的比较未见报道。本文中，笔者分别采用前列地尔及巴曲酶治疗LEAD，现对其疗效和经济性进行比较，并报道如下。
1资料与方法
1.1研究对象
选择2009年3月～2011年3月在本院就诊的LEAD患者40例，年龄37～74岁，病史0～10年，踝肱比(ABI)≤0.8，均1个月内经血管超声、造影DSA或核磁等影像学检查确诊，排除严重心、肝、肾功能不全及对药物过敏的患者。40例LEAD患者分成前列地尔组和巴曲酶组两组，前列地尔组20(男12、女8)例，平均年龄(56.2±10 ......
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