雷公藤多甙联合维生素E治疗小儿大量蛋白尿性急性肾小球肾炎疗效观察(1)
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[摘要] 目的 观察雷公藤多甙联合维生素E治疗大量蛋白尿性急性肾小球肾炎的临床疗效。方法 采用雷公藤多甙与维生素E治疗大量蛋白尿性急性肾小球肾炎33例，并与常规对照组33例对比。比较两组治疗1周后血压、血尿素氮(BUN)、血肌酐(Scr)变化情况及两组水肿、高血压、血尿、蛋白尿恢复时间、住院时间、临床疗效。结果 治疗组在临床疗效，水肿、高血压、血尿、蛋白尿恢复正常的时间和住院时间，治疗1周后对24h尿蛋白定量、SBP、DBP、BUN、Scr改善方面均优于对照组，差异均有统计学意义(P<0.05)。结论 雷公藤多甙与维生素E治疗大量蛋白尿性急性肾小球肾炎能较快的改善症状，提高临床疗效。
[关键词] 雷公藤多甙；维生素E；大量蛋白尿；急性肾小球肾炎
[中图分类号] R726.9 [文献标识码] B [文章编号] 1673-9701(2011)22-68-02
Observation of Effects of Tripterygium Wilfordii Polyglycosidium Combined with Vitamin E in Treating Acute Glomerulonephritis with Mass Proteinuria
ZHANG Ling
Qianxinan Prefecture Hospital in Guizhou Province，Qianxinan 562400，China
[Abstract] Objective To observe the effect of tripterygium wilfordii polyglycosidium combined with vitamin E in treating acute glomerulonephritis with mass proteinuria. Methods Divided 66 children of acute glomerulonephritis with mass proteinuria into two groups randomly，each group including 33 patients. The treating group was given tripterygium wilfordii polyglycosidium and vitamin E. The control group accepts convalescence method. After one week，Compared Bp，BUN，Scr of two groups；Compared the recovery time of HBP，hematuria，proteinuria，length of stay and clinical efficacy. Results Clinical efficacy，the recovery time of HBP，hematuria，proteinuria and length of stay in the treating group were statistically better than those in the control group(P<0.05)；after one week，Upro of 24h，SBP，DBP，BUN，Scr in the treating group were statistically improved than those in the comparing group(P<0.05). Conclusion Tripterygium wilfordii polyglycosidium and vitamin E can improve symptom of acute glomerulonephritis with mass proteinuria and can improve clinical efficacy.
[Key words] Tripterygium wilfordii polyglycosidium；Vitamin E；Mass proteinuria；Acute glomerulonephritis
以大量蛋白尿为主要表现的急性链球菌感染后肾小球肾炎(APSGN)临床表现与非大量蛋白尿APSGN有所不同，诊断和治疗常有一定困难。笔者于2005年3月～2011年3月以雷公藤多甙与维生素E治疗大量蛋白尿性急性肾小球肾炎，疗效满意，现报道如下。
1 资料与方法
1.1 一般资料
全部病例均为本院儿科门诊及住院患者，所有患儿均符合原发性肾小球疾病分型诊断标准[1]，且在起病2周内连续3次以上尿蛋白定性≥+++，或尿蛋白定量≥0.1g/(kg·d)。符合纳入标准的共66例，其中治疗组33例，男14例，女19例；年龄3～14岁，平均(5.16±1.24)岁；就诊时病程为2～4d ......
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