普米克令舒联合可必特雾化吸入治疗中重度AE-COPD临床疗效分析(1)
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[摘要] 目的 观察普米克令舒和可必特联合雾化吸入治疗中重度AE-COPD的治疗效果。方法 收集98例来我院治疗的中重度AE-COPD患者，随机分为观察组和对照组。对照组单独给予可必特治疗，观察组在此基础上给予普米克令舒，观察两组在用药前后症状、体征、动脉血气分析、肺功能等的变化。结果 观察组的显效率及总有效率明显高于对照组，差异有显著性(P<0.05)。与治疗前比较，观察组和对照组的PaO2及FEV1均明显升高，PaCO2明显降低，差异均有统计学意义(P<0.05)，但观察组的改善程度显著大于对照组(P<0.05)。结论 对于中重度AE-COPD患者采用普米克令舒和可必特两种药物联合雾化吸入治疗能够明显提高患者的治疗效果，且方法简单、易操作，对于提高患者的治疗依从性及生活质量具有重要意义。
[关键词] 普米克令舒；可必特；慢性阻塞性肺疾病；雾化吸入
[中图分类号] R563.9 [文献标识码] B [文章编号] 1673-9701(2011)23-96-02
Effect of Pulmicort Repules Combined with Combivent Inhaled on Patients with Moderate and Severe AE-COPD
ZHANG Wenxue
Department of Respiratory Medicine, Ningbo Municipal First Hospital in Zhejiang Province, Ningbo 315010, China
[Abstract] Objective To observe the treatment effect of Pulmicort repules combined with Combivent inhaled on patients with moderate and severe AE-COPD. Methods The patients selected from our hospital were randomly divided into observation group and control group, with 49 cases in each. Control group was given with Combivent and observation group was given with Pulmicort repules on the basis of control group. Symptoms, artery blood gas analysis and pulmonary function in two groups were observed after treatment. Results The efficiency rate and the overall response rate in the observation group were significant higher than those in the control group (P<0.05); Compared with before treatment, PaO2 and FEV1 were all increased and PaCO2 was decreased, but the improvement in the observation group was much higher than the control group, they all showed significant differences (P<0.05). Conclusion The effect of Pulmicort repules combined with Combivent inhaled on patients with moderate and severe AE-COPD could be enhanced, and it is simple and easy for operation, and it is importance to improve the treatment compliance and living quality of the patients.
[Key words] Pulmicort repules; Combivent; AE-COPD; Aerosol inhalation
慢性阻塞性肺疾病(COPD)是以慢性气流阻塞、不完全可逆性气流受限为特征的呼吸系统的多发病之一，可以预防和治疗。此种疾病主要是由患者的支气管黏膜炎症水肿加剧、痰液阻塞支气管，潮气量降低，导致肺泡的通气量不足引起的，常以咳嗽、咳痰、气短及喘息加重、痰液增多为主要临床表现[1] ......
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