过敏性紫癜儿童急性期血浆IL-13、IL-15水平的变化及意义(1)
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[摘要] 目的 探讨急性期过敏性紫癜患儿血浆IL-13、IL-15水平与过敏性紫癜发生发展的关系。方法 选择我院2009年1月～2010年12月收治的过敏性紫癜患儿共50例为观察组，另选择我院同期健康体检儿童50例为对照组，比较两组的IL-13、IL-15水平。再将观察组患儿按照有无肾脏受累症状分为肾损害组和无肾损害组两组，比较两组的IL-13、IL-15水平。结果 观察组与对照组患儿血浆IL-13、IL-15水平比较，差异均有统计学意义(P<0.05)；无肾损害组与肾损害组的IL-13、IL-15水平比较，差异均有统计学意义(P<0.05)。结论 IL-13、IL-15可能促进了过敏性紫癜的病程发展及肾损害的发展过程，在疾病发生发展中起着重要作用。
[关键词] 过敏性紫癜；白细胞介素-13、15；肾脏损害
[中图分类号] R554.6；R725.5 [文献标识码] B [文章编号] 1673-9701(2011)24-56-02
Changes of Plasma Interleukin 13，15 Levels in Children with Acute Phase Henoch-Schonlein Purpura and Significance
HU Linhai
Department of Pediatrics， Shaoxing City People's Hospital of Zhejiang Province， Shaoxing 312000， China
[Abstractl Objective To explore the relationship between plasma levels of IL-13， IL-15 and development of Henoch-Schonlein purpura (HSP) in children at acute phase of this disease. Methods Fifty cases of children with HSP treated in our hospital from January 2009 to December 2010 were selected as observation group and 50 children for physical examination at the same period were selected as control group. Plasma levels of interleukin 13， 15 of the two groups were compared. Children in observation group were divided into renal damage group and non renal damage group according to the symptoms of renal involvement， and plasma levels of interleukin 13， 15 of these two groups were also compared. Results Plasma IL-13， IL-15 levels of observation group compared with control group or renal damage group compared with non renal damage group， the differences were all statistically significant (P<0.05). Conclusion IL-13 and IL-15 may promote the courses of Henoch-Schonlein purpura and renal damage， and may play important roles in the development and progress of this disease.
[Key words] Henoch-Schonlein purpura； IL-13， 15； Renal damage
过敏性紫癜(Henoch-Schonlein purpura，HSP)是儿童时期一种较常见的微血管变态反应性出血性疾病，其病理基础为广泛的小血管炎症，病因有感染、食物过敏、药物过敏、花粉、昆虫咬伤等所致的过敏等，但过敏原因往往难以确定。儿童及青少年较多见，男性较女性多见，起病前1～3周往往有上呼吸道感染史。有报道[1]称，血管炎合并肾损害时，患儿体内的白细胞介素-13、15(IL-13、IL-15)的含量会显著升高。为探讨它们与过敏性紫癜的关系，本文对过敏性紫癜患儿血浆IL-13、IL-15水平进行检测，现报道如下。
1 资料与方法
1.1 一般资料
我院2009年1月～2010年12月收治HSP患儿共50例，其中男30例，女20例，年龄5～13岁，平均(7.3±1.9)岁，此50例患者为观察组；另选择我院同期健康体检儿童50例为对照组，其中男32例，女18例，年龄5～14岁，平均(7.5±1.5)岁；两组年龄、性别比较，差异无统计学意义(P>0 ......
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