胎盘生长因子在乙肝肝硬化组织中的表达及意义探讨(1)
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[摘要] 目的 研究胎盘生长因子(PLGF)在乙肝肝硬化组织中的表达及其意义。方法 对乙肝肝硬化终末期行肝移植术的切除肝10例和肝移植供体肝组织8例用RT-PCR和免疫组化方法检测PLGF mRNA及蛋白的表达。结果 PLGF mRNA和蛋白在肝硬化组织中有表达，均明显高于正常肝组织中的表达水平，差异有显著统计学意义(P<0.01)。结论 PLGF在乙肝肝硬化组织中表达增加，不仅参与其中的炎症过程，并且可能在肝硬化向肝癌发展的过程中起重要作用。
[关键词] 乙型病毒性肝炎；肝硬化；胎盘生长因子
[中图分类号] R575.2 [文献标识码] B [文章编号] 1673-9701(2011)24-76-02
Expression and Significance of Placenta Growth Factor in Tissue of Hepatic Cirrhosis after Viral Hepatitis Type B
LIN Shengdi1 CHEN Weilai2 PAN Chenwei3 LIN Wei3 TAO Chonglin4
1.Department of Intensive Care Unit， the Second Affiliated Hospital of Wenzhou Medical College， Wenzhou 325027， China； 2.Department of Neurology， the Third People's Hospital of Wenzhou， Wenzhou 325000， China； 3.Department of Infectious Disease， the Second Affiliated Hospital of Wenzhou Medical College， Wenzhou 325027， China； 4.Department of Hepatobiliary Surgery， the First Affiliated Hospital of Wenzhou Medical College， Wenzhou 325000， China
[Abstract] Objective To investigate expression of placenta growth factor(PLGF)in the tissue of hepatic cirrhosis after viral hepatitis type B， and to explore the clinical significance of PLGF. Methods Expression of PLGF mRNA and protein in surgical specimens which including 10 samples of hepatic cirrhosis liver tissue and 8 samples of normal hepatic tissues were detected by RT-PCR and immunohistochemistry respectively. Results Levels of mRNA and protein of PLGF expressed in hepatic cirrhosis liver tissue were higher than those in normal hepatic tissue significantly (all P<0.01). Conclusion PLGF which got higher expression in the tissue of hepatic cirrhosis not only take part in the processes of hepatic cirrhosis， but also possibly play important roles in the processes of tumorigenesis in hepatic cirrhosis liver tissue.
[Key words] Viral hepatitis type B； Hepatic cirrhosis； Placenta growth factor
肝硬化是一种常见的慢性肝病，是由一种或多种病因长期或反复作用，引起肝脏弥漫性损害。在我国，病毒性肝炎(尤其是乙型)是引起肝硬化的主要原因[1]。胎盘生长因子(placenta growth factor ......
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