立止血与双歧杆菌活菌联合治疗新生儿应激性溃疡疗效观察(1)
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[摘要] 目的 分析立止血与双歧杆菌活菌联合治疗新生儿应激性溃疡的临床疗效。方法 将我科住院66例NSU新生儿随机分为对照组与研究组。对照组予以常规治疗，研究组在此基础上予以立止血与双歧杆菌活菌联合治疗。分别记录两组新生儿呕血、黑便及止血的天数，检测胃黏膜pH值(pHi)以及消化道内容物的菌群种类。结果 研究组呕血、黑便及止血天数较对照组明显减少，pHi值也较对照组升高(P<0.05)；研究组消化道内容物的幽门螺杆菌、大肠杆菌与葡萄球菌检出率明显较低，而双歧杆菌和乳酸杆菌检出率明显增加(P<0.05)。结论 立止血与双歧杆菌活菌联合治疗新生儿应激性溃疡的临床疗效明显，且有助于改善消化道菌群失调。
[关键词] 新生儿；应激性溃疡；立止血；双歧杆菌活菌
[中图分类号] R722.1 [文献标识码] B [文章编号] 1673-9701(2011)24-81-02
Clinical Observation on Prevention of Neonatal Stress Ulcer with Reptilase and Bifido Bacterium Viable
WANG Yaqin
Pediatrics Department，Luqiao District Hospital of Traditional Chinese Medicine in Taizhou City，Zhejiang Province，Taizhou 318050，China
[Abstract] Objective To observe the prevention of neonatal stress ulcer with reptilase and bifido bacterium viable. Methods All 66 neonates suffered with stress ulcer were divided into control group and therapy group randomly. The control group received routine therapy，and the therapy group received reptilase and bifido bacterium viable，based on routine therapy. The durations of hematemesis，melena and hemostasis of the neonates in two groups were recorded. The pH of gastric intramucosa(pHi)of neonates and the kinds of bacterium in gastrointestinal content in two groups were detected. Results Compared to control group，the durations of hematemesis，melena and hemostasis of neonates in therapy group were obviously less，but the pHi of neonates in therapy group were higher(P<0.05). The detectable rates of helicobacter pylori，Escherichia coli and staphylococcus in therapy group were obviously lower than the control group，but the detectable rates of bifido and lactobacillus were obviously higher(P<0.05). Conclusion The combined treatment of reptilase and bifido bacterium viable can improve the clinic effect on neonatal stress ulcer and rectify the ecologic imbalance of neonatal gastrointestinal.
[Key words] Neonate；Stress ulcer；Reptilase；Bifido bacterium viable
新生儿应激性溃疡(neonatal stress ulcer，NSU)是因感染、缺氧、休克等诱因引起的急性胃、十二指肠黏膜损伤，表现多呈应激性胃溃疡及新生儿上消化道出血[1]。NSU若不及时治疗影响新生儿健康，严重可导致死亡[2]。我院应用立止血(北京托毕西药业，国药准字H20031074)与双歧杆菌活菌(丽珠制药厂 ......
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