大骨节Ⅰ号方治疗脾肾阳虚寒湿阻络型大骨节病的临床疗效观察*(1)
 |
| 第1页 |
参见附件(2789KB，3页)。
[摘要] 目的 与布洛芬缓释胶囊对照，评价大骨节Ⅰ号方胶囊治疗大骨节病的疗效。方法 选择大骨节病患者210例随机分为治疗组105例、对照组105例，分别予口服大骨节Ⅰ号方胶囊、布洛芬缓释胶囊。各组服用3个月后观察疗效，同时观察停药半年、1年的疗效。结果 3个月后，两组的疗效差异无统计学意义(P>0.05)，但治愈率、不良反应率差异有统计学意义(P<0.01或P<0.05)；停药半年、1年的随访观察中两组临床疗效、治愈率差异有统计学意义(P<0.01或P<0.05)。结论 大骨节Ⅰ号方胶囊治疗大骨节病的治愈率、不良反应率及远期疗效优于布洛芬缓释胶囊。
[关键词] 大骨节病；大骨节Ⅰ号方；布洛芬缓释胶囊
[中图分类号] R286 [文献标识码] B [文章编号] 1673-9701(2011)24-108-03
Clinical Observation of Kashin-Beck Ⅰ Treating Spleen and Kidney Yang Alpine Obstruction Syndrome in Kashin-Beck Disease
ZHANG Hongshen1 LUO Caigui2 XU Xueliang1 HUANG Zongjuan1 LUO Jian2 QIAN Junhui2 YANG Aiguo1 XU Rao1 WAN Yiwen1 ZHAO Can1
1.Chengdu University of Traditional Chinese Medicine，Chengdu 610075，China；2.Affiliated Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，China
[Abstract] Objective To evaluate the clinical efficacy of Kashin-Beck Ⅰ Capsule for Kashin-Beck disease. Methods We selected 210 cases of Kashin-Beck disease，and they were randomly divided into treatment group 105 patients which were given oral capsules of Kashin-Beck No. Ⅰ and control group 105 patients which were given cloth Ibuprofen sustained-release capsules. Two groups were taking medicine for more than 3 months to observe efficacy as well as its six months and one year follow-up observation of long-term efficacy of withdrawing. Results Three months after treatment，the efficacy of the two groups was no statistically significant (P>0.05)，but the cure rate，rate of adverse reactions was significant(P<0.01 or P<0.05)；the cure rate and total effective rate of six months and one year follow-up study of withdrawing of two groups was significant(P<0.01 or P<0.05). Conclusion The short-term cure rate，long-term efficacy and adverse reaction rates of Kashin-Beck Ⅰ capsules in Treating Kashin-Beck disease are better than ibuprofen capsules.
[Key words] Kashin-beck disease；Kashin-Beck Ⅰ；Ibuprofen capsules
大骨节病(kashin-beck disease，KBD)是一种病因不明的地方性、慢性、进行性、以四肢关节软骨和髓板软骨病变为主的骨关节病[1]。轻者关节增粗、疼痛，影响劳动能力；重者短肢畸形、丧失劳动能力，终生残疾。由于大骨节病病因不能确定，发病机制也尚未明确，目前为止还没具有针对性的特效药物以及治疗手段。在四川省阿坝州壤塘县等[2]大骨节病重病区，大骨节病患者因治疗用药不当等因素而导致病情加重非常普遍 ......
您现在查看是摘要介绍页，详见PDF附件(2789KB，3页)。