人工肝对慢性重型肝炎远期预后的影响*(1)
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[摘要] 目的 探讨人工肝对慢性重型肝炎肝衰竭远期预后的影响。方法 回顾性分析199例慢性乙型重型肝炎患者，分为人工肝治疗组101例和内科治疗对照组98例，随访3年内患者肝功能CTP分级及存亡状态，两组之间构成比的比较采用χ2检验，采用Kaplan-Meier方法进行生存分析，生存率比较采用Log-Rank检验。结果 不同治疗组肝功能分级的构成比只有半年时差异有统计学意义(χ2=8.358，P=0.015)。治疗后1、2、3年时的差异均无统计学意义。治疗组3年生存率高于对照组，差异有统计学意义(χ2=3.840，P=0.050)。结论 人工肝对促进慢性重型肝炎近期恢复疗效确切，对远期肝功能演变无明显影响，但可显著提高慢性重型肝炎患者的远期生存率。
[关键词] 人工肝；慢性重型肝炎；远期预后
[中图分类号] R575.1 [文献标识码] B [文章编号] 1673-9701(2011)24-159-02
The Effect of Artificial Liver on Long-term Prognosis of Chronic Hepatitis Gravis
NIU Chuanzhen ZOU Zhiqiang YANG Shaoping YU Jiguang ZHANG Fuhua MU Shufen GUO Yanmei YU Shengmei LIU Youde ZHAO Xiuqin WANG Cuiying XIE Hui
Yantai Infectious Diseases Hospital， Yantai 264001， China
[Abstract] Objective To assess the effect of artificial liver on the long-term prognosis of hepatic failure caused by chronic hepatitis gravis. Methods A retrospective analysis was made among 199 cases of chronic hepatitis B gravis， which were divided into the treatment group (artificial liver，101 cases) and the control group (conventional medical treatment，98 cases)， with a three-year follow-up of liver function CTP grading and survival condition. χ2 test was taken to make a comparison in constituent ratio between the two groups and Kaplan-Meier method was adopted to make an analysis of survival condition， comparing survival rate with Log-Rank test. Results There was a significant difference in constituent ratio of liver function grading between the two groups (χ2=8.358，P=0.015) only at the middle of a year， with no significant difference at one year， two years and three years after the treatment. Three-year survival rate in the treatment group was higher than that in the control group， with significant difference (χ2=3.840，P=0.050). Conclusion Artificial liver is quite a help to the short-term recovery from chronic hepatitis gravis， with a reliable curative effect， and brings about little effect on long-term development of the liver function. But it can remarkably prolong the long-term survival time of those with chronic hepatitis B gravis ......
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