白细胞介素-6水平在急性心肌梗死再灌注冠脉介入治疗过程中的变化(1)
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[摘要]目的 观察急性ST段抬高型心肌梗死(STEAMI)患者行急诊经皮冠状动脉介入治疗(PCI)术前、术后白细胞介素-6(IL-6)浓度变化与无复流(NR)的关系，探讨其临床意义。方法 将发病12h内接受急诊PCI治疗，术后造影显示TIMI 3级血流的STEAMI患者42例分为无复流组和再灌流组。应用酶联免疫吸附试验(ELISA)检测患者血清IL-6浓度。结果 无复流组较再灌注组术后各时间点IL-6水平明显增高(P<0.05)，两组术后24h、48h的IL-6浓度与术前比较均有明显增高(P<0.05)。结论AMI患者急诊PCI术后血清IL-6浓度增高可作为筛选无复流的潜在生化指标。
[关键词] 急性ST段抬高型心肌梗死；急诊经皮冠状动脉介入治疗；无复流；白细胞介素-6
[中图分类号] R541.4[文献标识码]B[文章编号] 1673-9701(2011)25-67-03
The Changes of Serum Interleukin-6 in Patients of No Reflow with Acute Myocardial Infarction after Primary Percutaneous Coronary Intervention
LIMingzhe1ZHAO Lihua2
1.Siping City Central Hospital，Siping 136000，China；2.Department of Cardiology，the First Hospital of Jilin University，Changchun 130021，China
[Abstract] Objective To observe the interleukin(IL-6) levels at different time in the patients with ST segment elevation acute myocardial infarction before and after pecutaneous coronary intervention and to evaluate the clinical significance. Methods To seclect the clinical case and experimental design： 42 patients with ST segment elevation acute myocardial infarction(STEAMI) with successfully treated by PCI within 12h of onset and showedThrombosis in Myocardial Infarction(TIMI)grade 3 blood flow by coronary arteriongraphy after operation were divided into reperfusion and no-reflow. Enzyme linked immunosorbent assay(ELISA) was used for the detection of IL-6. ResultsThe IL-6 levels at all times of post-operation have significant difference in the non reperfusion group and reperfusion group. Moreover，the IL-6 levels all obviously increased at 24h and 48h after operation in both groups (P<0.05). Conclusion High IL-6 levels in the blood of AMI patient after emergency PCI surgery could be considered as screening index of no reflow(especially at 48h of post-operation).
[Key words] ST segment elevation acute myocardial infarction；Percutaneous coronary intervention；No reflow； IL-6
随着人民生活水平的不断提高，急性心肌梗死(AMI)的发病率逐年增加，已经成为严重危害人类健康的重大公共卫生问题。及时开通梗死相关动脉、有效地恢复梗死心肌再灌注是AMI的根本治疗手段，能够明显降低心肌梗死的死亡率。在急诊经皮冠状动脉介入治疗(PCI)已经成为AMI标准化治疗的今天 ......
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