拉米夫定\来氟米特和中药联合治疗乙型肝炎病毒相关性膜性肾病的临床研究(1)
 |
| 第1页 |
参见附件(1975KB，2页)。
[摘要] 目的 探讨拉米夫定、来氟米特联合中药方剂治疗乙型肝炎病毒相关性膜性肾病(HBV-MN)的临床疗效。方法 患者均口服拉米夫定、来氟米特，研究组患者加服中药组方，治疗6个月，分别对经测血清白蛋白(ALB)、丙氨酸氨基转移酶(ALT)、血清胆固醇(CHO)、尿蛋白定量和临床疗效做出评价。结果 患者治疗6个月后，研究组ALT、CHO和尿蛋白定量[(45.8±10.3)、(5.7±1.4)、(1.5±1.3)]较对照组[(73.8±28.9)、(8.4±2.2)、(6.8±3.6)]均明显降低，ALB(33.9±5.3)较对照组(25.5±8.2)升高，数据经统计学比较具有显著差异(P<0.05)。研究组患者经6个月中西结合治疗后总有效率(100.00%)明显高于对照组(77.27%)(P<0.05)。结论 联合应用拉米夫定、来氟米特和中药治疗HBV-MN具有较好的临床疗效，能够更明显地改善ALB、ALT、CHO和尿蛋白定量，改善和调理患者肝、肾、脾的损伤。
[关键词] 拉米夫定；来氟米特；中药治疗；乙型肝炎；膜性肾病
[中图分类号] R692.9；R512.62[文献标识码] B [文章编号] 1673-9701(2011)25-81-02
Clinical Study of Hepatitis B Virus Associated Membranous Nephropathy Treated by Lamivudine，Leflunomide Combined with Chinese Medicine
DUAN Yangri
Hangzhou City Yuhang District the Third People’s Hospital，Hangzhou 311115，China
[Abstract] Objective To discuss the clinical effects of hepatitis B virus associated membranous nephropathy(HBV-MN) treated by lamivudine，leflunomide combined with Chinese medicine. Methods Patients were taken orally lamivudine and leflunomide. Study group added Chinese medicine for 6 months，then valued the ALB，ALT，CHO，urinary protein and clinical effects. Results Compared with Control Group(73.8±28.9，8.4±2.2，6.8±3.6)，ALT，CHO and urinary protein of study group(45.8±10.3，5.7±1.4，1.5±1.3) were significantly reduced，ALB of study group (33.9±5.3) was higher than control group (25.5±8.27)(P<0.05). The total effective rate of study group(100%) was significantly higher than control group(77.27%)(P<0.05). Conclusion It has good effect of hepatitis B virus associated membranous nephropathy(HBV-MN) treated by lamivudine，leflunomide combined with Chinese medicine. It could significantly lower ALB，ALT，CHO，urinary protein and improve the hurt in liver，kidney，spleen of patients.
[Key words] Lamivudine；Leflunomide；Chinese Medicine Treatment；Hepatitis B Virus；Membranous Nephropathy
乙型肝炎病毒相关性膜性肾病(Hepatitis B Virus Associated Membranous Nephropathy，HBV-MN)属于继发性肾小球疾病，在临床较为常见。对于HBV-MN的临床治疗，目前医学界尚未确立较为特效的方法，临床现行治疗方法主要包括抗病毒、免疫抑制剂、激素、中药等[1]，相关的研究文献也较少。本研究选取我院2010年1～12月诊治的患者44例行临床研究，以探讨拉米夫定、来氟米特联合中药治疗HBV-MN的临床疗效 ......
您现在查看是摘要介绍页，详见PDF附件(1975KB，2页)。