克林澳联合依达拉奉治疗急性脑梗死疗效观察(1)
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[摘要] 目的 探讨克林澳(马来酸桂哌齐特)联合依达拉奉注射液治疗急性脑梗死的临床疗效。方法 选择我院神经内科收治的急性脑梗死患者168例作为研究对象，随机分为两组。对照组单用克林澳，治疗组使用克林澳联合依达拉奉治疗。比较两组的临床疗效、神经功能缺损评分和欧洲脑卒中评分量表(ESS)评分。结果 两组患者治疗后临床疗效、神经功能缺损评分和ESS 评分的差异有显著性(P<0.05或P<0.01)。结论 克林澳联合依达拉奉注射液治疗急性脑梗死安全有效，能显著改善患者的预后。
[关键词] 脑梗死；克林澳；依达拉奉；自由基清除剂
[中图分类号] R743.3 [文献标识码] B[文章编号] 1673-9701(2011)25-83-02
Therapeutic Efficacy of Cinepazide Maleate-edaravon Combination on Acute Brain Infarction
GAO XimingXING Shirong
Department of Neurology，Lianshan District People's Hospital of Huludao City in Liaoning Province，Huludao 125001，China
[Abstract] Objective To investigate the therapeutic efficacy of cinepazide maleate-edaravone combination on acute brain infarction.Methods One hundred and sixty eight patients with acute brain infarction in the department of neurology of our hospital were enrolled into the study and randomly divided into two groups. The patients in control group were treated with the cinepazide maleate，the patients in treatment group were treated with cinepazide maleate-edaravone combination. The clinical efficacy、neurologic impairment scores and the scores of European Stroke Scale of two groups were compared. Results Compared with those before treatment，there were significant differences in the clinical efficacy、neurologic impairment scores and the scores of European Stroke Scale between the two groups(P<0.05 or P<0.01). Conclusion Cinepazide maleate-edaravone combination is safe and effeetive to impprove the
neurological function and the ability of dailyliving for acute cerebral infarction.
[Key words] Acute brain infarction；Cinepazide maleate；Edaravon；Free radical scavenger
急性脑梗死是神经内科的多发病和常见病，有很高的死亡率及致残率， 严重影响人类生命健康。克林澳联合依达拉奉注射液治疗84例急性脑梗死，取得较为满意的疗效，现将结果报道如下。
1资料与方法
1.1一般资料
选择2010年1月～2011年5月在我院神经内科住院的168例急性脑梗死患者，诊断均符合1995年中华医学会全国第四届脑血管病学术会议制订的脑梗死诊断标准[1]，并经头颅CT或MRI证实；排除颅内出血性疾病、昏迷或大面积脑梗死者，严重造血系统疾病、有出血倾向者，严重精神疾病或痴呆以及对本药过敏者；将入选的168例患者(病程6～72h，均为首次发病)随机分为两组：治疗组84例，男48例，女36例；年龄45～82岁，平均(61.2±2.4)岁；其中有高血压病史20例，高脂血症28例，冠心病史14例，糖尿病史 22例；腔隙性脑梗死22例，小脑梗死9例，脑桥梗死 6例，内囊基底节区梗死 43例 ......
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