冠心宁注射液治疗非ST段抬高急性冠脉综合征临床疗效观察(1)

http://www.100md.com 2011年9月5日 夏森林 汪艳

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     [摘要] 目的 观察冠心宁注射液辅助西医治疗非ST段抬高的急性冠脉综合征的临床疗效。方法 选择非ST段抬高的急性冠脉综合征患者108例，随机分为治疗组、对照组各54例，两组均给予西医常规治疗，治疗组加用冠心宁注射液治疗，观察两组临床疗效、心绞痛缓解程度、心电图改善情况，检测凝血功能、血小板计数变化，记录药物不良反应。结果 治疗组的心绞痛缓解程度及心电图改善情况显著高于对照组(P<0.01)，对凝血功能及血小板计数无明显影响(P>0.05)，两组均未见严重的药物不良反应。结论 冠心宁注射液辅助治疗非ST段抬高的急性冠脉综合征能显著提高临床疗效。

    [关键词] 非ST段抬高的急性冠脉综合征；冠心宁注射液

    [中图分类号] R541.4 [文献标识码] B [文章编号] 1673-9701(2011)25-99-02

    Effects of Guanxinning Injection on Non-ST-segment Elevation Acute Coronary Syndrome

    XIA SenlinWANG Yan

    Huzhou Central Hospital in Zhejiang Province, Huzhou 313000, China

    [Abstract] Objective To observe the effects of Guanxinning injection on non-ST-segment elevation acute coronary syndrome. Methods A total of 108 patients with non-ST-segment elevation acute coronary syndrome were randomly divided into two groups: the treatment group (54 cases) and the control group (54 cases). Both groups were treated with standard therapy. The treatment group was given additionally with Guanxinning injection. Therapeutic effects, angina relieves, ECG improvement, adverse drug reactions, changes of coagulation function and platelet counts before and after the treatment were observed. Results Both the angina relieves and ECG improvement shown in the treatment group were significantly better than that in the control group (P<0.01), while there was no significant diffrence between the changes of coagulation function and platelet counts of the two groups (P>0.05). Serious adverse drug reactions were not be observed. Conclusion Guanxinning injection for non-ST-segment elevation acute coronary syndrome could significantly improve the therapeutic effetcts.

    [Key words] Non-ST-segment elevation acute coronary syndrome; Guanxinning injection

    非ST段抬高急性冠脉综合征(NSTE-ACS)包括不稳定型心绞痛(UA)及非ST段抬高型心肌梗死(NSTEMI)，目前针对NSTE-ACS的药物治疗包括抗心肌缺血治疗、抗血小板治疗、抗凝、他汀类、硝酸酯类、ACEI或ARB类以及应用β受体阻滞剂等，我们在西医常规治疗基础上应用冠心宁注射液辅助治疗NSTE-ACS，取得了满意疗效，现报道如下。

    1资料与方法

    1.1一般资料

    2008年10月～2010年10月我院住院的非ST段抬高型急性冠脉综合征108例，其中男68例，女40例；平均年龄为(64±13)岁，胸痛时间(1.29±0.58)h，ST段压低(1.51±0.24)mm。诊断标准：符合2007年ACC/AHA及欧洲心血管病杂志关于UA、NSTEM的诊断标准。全部患者分为治疗组54例(男35例，女19例)，其中不稳定型心绞痛39例，非ST段抬高型心肌梗死15例；对照组54例(男33例，女21例)，其中不稳定型心绞痛37例，非ST段抬高型心肌梗死17例。病例排除标准：除外合并甲状腺疾病、风湿性疾病、恶性肿瘤、严重肝肾功能不全、心衰Ⅲ度以及AMI经静脉溶栓、急诊冠状动脉介入治疗的患者 ......

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