棓丙酯治疗急性脑梗死疗效的Meta分析(1)
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[摘要] 目的 探讨棓丙酯治疗急性脑梗死的疗效。方法 按照系统评价的要求全面检索了中国期刊全文数据库和万方数字化期刊数据库，对符合纳入标准的10篇文献共计991名患者进行了Meta分析。结果 发表性偏倚分析显示10篇文献的倒漏斗图是对称的。异质性检验棓丙酯组与阳性对照组具有临床及统计学上的同质性(P=0.45，I2=0%)，可用固定效应模型进行分析；棓丙酯组与空白对照组不具有统计学上的同质性(P=0.04，I2=64.9%)，故用随机效应模型进行分析。合并分析显示：棓丙酯治疗急性脑梗死与对照组比较，疗效差异有统计学意义。结论 从现有的临床证据来看，棓丙酯治疗急性脑梗死有效，棓丙酯与对照组相比，疗效较高，但缺少大样本、严格设计的随机双盲对照试验，证据强度较低。
[关键词] 棓丙酯；急性脑梗死；Meta分析
[中图分类号] R743.3[文献标识码] B [文章编号] 1673-9701(2011)27-62-02
A Meta-analysis of Treatment of Acute Cerebral Infarction with Propylgallate
LIU Guiqin1JIN Yonghua2
1.Department of Pharmacy，Dongda Hospital ofShanxian，Shandong Province，Shanxian 274300，China；2. Pharmacology Department，China Pharmaceutical University，Nanjing210009，China
[Abstract] Objective To assess the efficacy of propylgallate in treatment of acute cerebral infarction. Methods According to the requirements of Cochrane systematic review，a thorough literature search was performed among China Series full-text database and Wanfang Digital Periodical Database. A meta analysis was performed on a total of 991 patients involved in 10 papers which met the inclusion criteria. Results Publication bias analysis showed that the funnel plot was symmetrical. Test for heterogeneity showed that the groups treated with propylgallate and active control had clinical homogeneity and statistical homogeneity (P=0.45，I2=0%)，which allowed to use fixed effect model analysis. The propylgallate and placebo did not have statistical homogeneity(P=0.04，I2=64.9%)，therefore random effect model analysis was applied. Incorporation analysis showed that effectiveness of propylgallate is statistically significant different from control. Conclusion The clinical evidences available so far indicated that treatment of acute cerebral infarction with propylgallate is effective although rigorously designed large sample size randomized double blind clinical trials are required to further demonstrate and support the conclusion.
[Key words] Propylgallate；Acute cerebral infarction；Meta-analysis ......
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