多索茶碱联合甲强龙治疗毛细支气管炎疗效观察(1)
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[摘要] 目的 探讨提高毛细支气管炎疗效的有效方法。方法 选择符合毛细支气管炎诊断标准的住院患儿90例，随机分为治疗组、对照组各45例。两组入院后均给予常规吸氧、抗感染及雾化吸入、吸痰、止咳化痰等对症支持治疗。治疗组加用多索茶碱联合甲泼尼龙琥珀酸钠(甲强龙)静脉滴注，对照组只加用氨茶碱静脉滴注，疗程均3～5d，观察两组患儿的疗效。结果 治疗组的显效率及总有效率均高于对照组，差异均有统计学意义(P均<0.05)；治疗组的主要症状、体征完全缓解时间短于对照组，差异均有统计学意义(P均<0.05)；治疗组总不良反应发生率低于对照组，差异有统计学意义(P<0.01)。结论 在常规治疗基础上加用多索茶碱联合甲强龙治疗毛细支气管炎，疗效显著、安全，是提高毛细支气管炎疗效的有效方法。
[关键词] 毛细支气管炎；多索茶碱；甲泼尼龙琥珀酸钠
[中图分类号] R725.6[文献标识码] B [文章编号] 1673-9701(2011)27-80-02
Clinical Effects of Doxofylline with Methylprednisolone on Bronchiolitis
CHEN Liya
Pediatrics Department，the People's Hospital of Shengzhou City，Zhejiang Province，Shengzhou 312400，China
[Abstract] Objective To investigate the effect of doxofyline combined with methylprednisolone in treating the children with bronchiolitis. Methods All 90 patients who were diagnosed with bronchiolitis were simply randomized to the control group and the treated group.The treated group (45 cases) were given doxofyline combined with methylprednisolone and the control group (45 cases) were given aminophylline. Clinical characteristics were compared. Results The total efficacy rates of bronchiolitis in the treated group were higher than those of the control group(P<0.05). The time of clinical symptom relief of the treated group were less than those of the control group(P<0.05). Moreover，the rate of adverse effect of the treated group were less than those of the control group(P<0.01). Conclusion Doxofyline combined with methylprednisolone therapy has advantages of signiticant therapeutic effect，rapid relieving symptoms and lower rate of adverse effect in treating the children with bronchiolitis.
[Key words] Bronchiolitis；Doxofyline；Methylprednisolone
毛细支气管炎是一种婴幼儿较常见的下呼吸道感染，以喘憋、三凹征和气促为主要临床特点。至今对毛细支气管炎仍然没有令人满意的特效治疗。为探讨提高毛细支气管炎疗效的有效方法，我们用多索茶碱联合甲泼尼龙琥珀酸钠(甲强龙)治疗毛细支气管炎，疗效显著，现总结报道如下。
1资料与方法
1.1一般资料
选择2009年12月～2011年3月在本院儿科住院治疗的90例毛细支气管炎患儿，均符合毛细支气管炎诊断[1]，且无其他合并症。其中男54例，女36例，年龄48d～18个月，其中48d～6个月61例，7～18个月29例，均为急性起病，发病3d内入院。入院时均有阵发性咳嗽、喘憋、气促、三凹征、呼吸困难 ......
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