小剂量氨茶碱辅助治疗咳嗽变异性哮喘的疗效观察(1)
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[摘要]目的 探讨小剂量氨茶碱辅助治疗咳嗽变异性哮喘的临床疗效。方法100例咳嗽变异性哮喘患者根据所用药物的不同分为A组(n=55例,常规治疗)和B组(n=45例,在常规治疗的基础上给予小剂量氨茶碱治疗),比较两组的疗效、治疗前后哮喘发作次数以及每次发作的持续时间、肺功能的变化。结果在常规吸氧、止咳、化痰、平喘、抗炎等对症支持治疗的基础上应用氨茶碱后,B组的疗效明显优于A组(P<0.05),且B组的哮喘发作次数以及每次发作持续时间明显低于对照组(P<0.05)。B组的肺功能改善较对照组更明显(P<0.05)。 结论 小剂量氨茶碱辅助治疗咳嗽变异性哮喘疗效确切,能明显降低患者的发作次数以及发作时间,改善患者的肺功能,值得推广和应用。
[关键词]咳嗽变异型哮喘;氨茶碱;小剂量
[中图分类号] R562.25[文献标识码]B [文章编号] 1673-9701(2011)27-89-02
Low-dose Aminophylline AssistedTreatment Cough Bariant Asthma
LI Zhonghua
Bao'an District Guanlan People's Hospital inShenzhenCity,Shenzhen 518110, China
[Abstract] ObjectiveTo investigate theclinical efficacy of adjuvant treatment low-dose theophylline cough variant asthma. Methods All100 patients were divided into group A (n=55 patients, conventional treatment) and group B (n=45 cases, on the basis of conventional therapy to give a small dose of aminophylline treatment) . ResultsIn normal oxygen, cough, phlegm, asthma, inflammatory, symptomatic and supportive treatment based on the application after aminophylline, B group was significantly better than group A(P<0.05),and number of asthma attacks and duration of each episode of group B was significantly lower than group A (P<0.05). Group B which improved lung function was more significantly than group A(P<0.05). Conclusion Low-dose theophylline assisted cough variant asthma is effective, patients can significantly reduce the number of attacks and the onset time, and to improve lung function, it should be promoted and applied.
[Key words] Cough variant asthma;Aminophylline;Small doses
咳嗽变异性哮喘(cough variant asthma,CVA)是指以慢性咳嗽为主要或唯一临床表现的一种特殊类型哮喘,应及早进行诊断并积极进行治疗[1- 2]。该病目前治疗主要是应用β2受体激动剂、茶碱类、抗组胺类药物、免疫调节剂、皮质激素等药物治疗,但疗效各异[3]。本研究旨在探讨在常规治疗的基础上应用小剂量氨茶碱辅助治疗咳嗽变异性哮喘的临床疗效,现分析如下。
1资料与方法
1.1 临床资料
选取我院2008年1月~2010年1月内科收治的咳嗽变异性哮喘患者100例作为观察对象,年龄18~70岁,平均年龄(42.7±5.4)岁, 临床表现主要为慢性持续性干咳、以夜间和清晨咳嗽为主,痰少,无发热。运动后、吸入冷空气后咳嗽加重, 伴有不同程度咽痒、鼻塞、流涕。根据所用药物不同分为A组(n=55例,常规治疗)和B组(n=45例,在常规治疗的基础上给予小剂量氨茶碱治疗),两组患者的年龄、性别、病程等一般资料经统计学分析处理 ......
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