高尿酸血症与其他代谢异常相关性的研究(1)
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[摘要] 目的 探讨高尿酸血症和其他代谢异常的相关性。方法 对来我院进行健康体检的1780例健康人群进行调查，观察在健康人群中高尿酸血症和其他代谢综合征的患病情况，对调查的结果进行分析。结果 研究对象中13.43%患有高尿酸血症；其他的代谢异常分别为肥胖、高血压、空腹高血糖、高TC、高TG、高LDL-C、低HDL-C、高nonHDL-C及脂肪肝，其患病率分别为 11.8%、28.9%、20.2%、34.0%、26.4%、36.3%、31.7%、21.3%、39.8%。与非高尿酸血症组比较，代谢异常在高尿酸血症中患病率较高；分别对患者的年龄和性别进行调整，但两组间仍有显著性差异(P<0.05)。多元Logistic回归分析结果发现，与血清尿酸水平有独立相关性的因素为肥胖、高血压、低HDL-C、高TG及脂肪肝。结论 高尿酸血症能够使其独立相关因素的代谢异常发生危险性加大。
[关键词] 高尿酸血症；代谢异常；相关性
[中图分类号] R589 [文献标识码] A [文章编号] 1673-9701(2011)32-13-03
Hyperuricemia and Its Correlation with Other Metabolic Abnormalities
WU Qiuhua
Department of Laboratory, Zhejiang Province Huzhou City the First People's Hospital, Huzhou 313000, China
[Abstract] Objective To observe the relation of hyperuricemia and other metabolic abnormalities. Methods In this study, 1780 healthy subjects to our hospital for health examination were observed hyperuricemia and other metabolic syndrome prevalence, using statistical methods to analyze the results of the survey. Results There were 13.43% subjects with hyperuricemia; other metabolic disorders were obesity, hypertension, fasting hyperglycemia, high TC, high TG, high LDL-C, low HDL-C, high nonHDL-C and fatty liver, the prevalence rates were 11.8%, 28.9%, 20.2%, 34.0%, 26.4%, 36.3%, 31.7%, 21.3%, 39.8%. Compared with non-hyperuricemia group, metabolism in the hyperuricemia group was higher; we adjusted the patient's age and gender, but there was still significant difference between the two groups(P<0.05). Multiple logistic regression analysis found that serum uric acid levels of the factors independently associated with obesity, hypertension, low HDL-C, high TG and fatty liver. Conclusion Hyperuricemia related to its independent factors increasing the risk of occurrence of metabolic abnormalities.
[Key words] Hyperuricemia; Metabolism abnormalities; Correlation
高尿酸血症是一种代谢性疾病，其是痛风的生化基础，有研究报道，高尿酸血症与各种心血管疾病具有密切的关系，严重影响其发病率和死亡率[1]。本研究对2010年1~12月来我院进行健康体检的1780例健康人群进行调查，观察在健康人群中高尿酸血症和其他代谢综合征的患病情况，并用统计学方法对调查的结果进行分析。现将研究结果进行分析报道如下。
1 资料与方法
1.1 临床资料
收集2010年1~12月来我院进行健康体检的1780例健康人作为研究对象，其中年龄最小36岁，最大92岁，平均年龄(55.1±17.3)岁，其中男502例，女1278例，男女比例为1：2.55。
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