双胎妊娠早孕期非整倍体筛查的研究现状(2)
综上所述，目前双绒毛膜双胎的血清学联合NT筛查比较理想，而单绒毛膜双胎仍不理想，由于单绒双胎间胎盘血液相通、双胎发育不一致导致NT差异等对筛查结果影响很大。三胎以上妊娠目前还没有好的筛查办法，因此对于多胎以及单绒毛膜双胎的筛查还需要进一步研究，以寻找有效的筛查方法。
[参考文献]
[1] 乐杰. 妇产科学[M]. 第5版. 北京：人民卫生出版社，2002：149.
[2] Quarello E，Ville Y. Screening for aneuploidies in twins[J]. Gynecologie Obstetrique & Fertilite，2007，35(12)：1195-1203.
[3] Krantz DA，Hallahan TW，Macri VJ，et al. Genetic sonography after first-trimester Down syndrome screening[J]. Ultrasound in Obstetrics & Gynecology，2007，29(6)：666-670.
, 百拇医药
[4] Wald NJ，Densem JW，George L，et al. Prenatal screening for Down’s syndrome using inhibin-A as a serum marker[J]. Prenatal Diagnosis，1996，16(2)：143-153.
[5] Bush MC，Malone FD. Down syndrome screening in twins[J]. Clinics in Perinatology， 2005，32(2)：373-386.
[6] 金昱，沈敏，吕时铭. 孕中期双胎妊娠与单胎妊娠孕妇血清AFP与F-β-HCG水平的比较[J]. 中国应用生理学杂志，2007，23(2)：147-149.
[7] Odibo AO，Lawrence-Cleary K，Macones GA. Screening for aneuploidy in twins and higher-order multiples: is first-trimester nuchal translucency the solution?[J]. Obstetrics and Gynecological Survey，2003，58(9)：609-614.
, 百拇医药
[8] Malone FD，D’Alton ME. First-trimester sonographic screening for Down syndrome[J]. Obstertrics and Gynecology，2003，102(5 Pt 1)：1066-1079.
[9] Sepulveda W，Wong AE，Casasbuenas A. Nuchal translucency and nasal bone in first-trimester ultrasound screening for aneuploidy in multiple pregnancies[J]. Ultrasound in Obstetrics & Gynecology，2009，33(2)：152-156.
[10] Odibo AO，Elkousy MH，Ural SH，et al. Screening for aneuploidy in twin pregnancies: maternal age-and race-specific risk assessment between 9-14 weeks[J]. Twin Research，2003，6(4)：251-256.
, http://www.100md.com
[11] Spencer K，Salonen R，Muller F. Down’s syndrome screening in multiple pregnancies using alpha-fetoprotein and free beta hCG[J]. Prenatal Diagnosis，1994，14(7)：537-542.
[12] Chasen ST，Perni SC，Predanic M，et al. Does a“vanishing twin”affect first-trimester biochemistry in Down syndrome risk assessment?[J]. American Journal of Obstetrics and Gynecology，2006，195(1)：236-239.
[13] Spencer K，Staboulidou I，Nicolaides KH. First trimester aneuploidy screening in the presence of a vanishing twin: implications for maternal serum markers[J]. Prenatal Diagnosis，2010，30(3)：235-240.
[14] Sperling L，Tabor A. Twin pregnancy: the role of ultrasound in management[J]. Acta Obstetricia et Gynecologica Scandinavica，2001，80(4)：287-299.
(收稿日期：2011-08-10), 百拇医药(陈藕景 朱莉 王亚萍)
[参考文献]
[1] 乐杰. 妇产科学[M]. 第5版. 北京：人民卫生出版社，2002：149.
[2] Quarello E，Ville Y. Screening for aneuploidies in twins[J]. Gynecologie Obstetrique & Fertilite，2007，35(12)：1195-1203.
[3] Krantz DA，Hallahan TW，Macri VJ，et al. Genetic sonography after first-trimester Down syndrome screening[J]. Ultrasound in Obstetrics & Gynecology，2007，29(6)：666-670.
, 百拇医药
[4] Wald NJ，Densem JW，George L，et al. Prenatal screening for Down’s syndrome using inhibin-A as a serum marker[J]. Prenatal Diagnosis，1996，16(2)：143-153.
[5] Bush MC，Malone FD. Down syndrome screening in twins[J]. Clinics in Perinatology， 2005，32(2)：373-386.
[6] 金昱，沈敏，吕时铭. 孕中期双胎妊娠与单胎妊娠孕妇血清AFP与F-β-HCG水平的比较[J]. 中国应用生理学杂志，2007，23(2)：147-149.
[7] Odibo AO，Lawrence-Cleary K，Macones GA. Screening for aneuploidy in twins and higher-order multiples: is first-trimester nuchal translucency the solution?[J]. Obstetrics and Gynecological Survey，2003，58(9)：609-614.
, 百拇医药
[8] Malone FD，D’Alton ME. First-trimester sonographic screening for Down syndrome[J]. Obstertrics and Gynecology，2003，102(5 Pt 1)：1066-1079.
[9] Sepulveda W，Wong AE，Casasbuenas A. Nuchal translucency and nasal bone in first-trimester ultrasound screening for aneuploidy in multiple pregnancies[J]. Ultrasound in Obstetrics & Gynecology，2009，33(2)：152-156.
[10] Odibo AO，Elkousy MH，Ural SH，et al. Screening for aneuploidy in twin pregnancies: maternal age-and race-specific risk assessment between 9-14 weeks[J]. Twin Research，2003，6(4)：251-256.
, http://www.100md.com
[11] Spencer K，Salonen R，Muller F. Down’s syndrome screening in multiple pregnancies using alpha-fetoprotein and free beta hCG[J]. Prenatal Diagnosis，1994，14(7)：537-542.
[12] Chasen ST，Perni SC，Predanic M，et al. Does a“vanishing twin”affect first-trimester biochemistry in Down syndrome risk assessment?[J]. American Journal of Obstetrics and Gynecology，2006，195(1)：236-239.
[13] Spencer K，Staboulidou I，Nicolaides KH. First trimester aneuploidy screening in the presence of a vanishing twin: implications for maternal serum markers[J]. Prenatal Diagnosis，2010，30(3)：235-240.
[14] Sperling L，Tabor A. Twin pregnancy: the role of ultrasound in management[J]. Acta Obstetricia et Gynecologica Scandinavica，2001，80(4)：287-299.
(收稿日期：2011-08-10), 百拇医药(陈藕景 朱莉 王亚萍)