替米沙坦对2型糖尿病合并高血压患者胰岛素抵抗及APN的影响(1)
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[摘要] 目的 探讨替米沙坦对2型糖尿病合并高血压患者胰岛素抵抗及APN的影响。方法 将80例高血压合并2型糖尿病确诊患者随机分为替米沙坦组和对照组，每组40例。在口服降血糖基础上，替米沙坦组给予替米沙坦片治疗；对照组给予氨氯地平片治疗。结果 所有患者在治疗10周后血压均达到140/90mmHg以下，治疗10周后两组SBP、DBP比较，无显著性差异(P>0.05)。治疗前两组FBS、FIns、HOMA-IR、APN比较无显著性差异(P>0.05)。治疗10周后，替米沙坦组HOMA-IR较对照组明显降低(P<0.05)，外周血APN含量较对照组明显升高(P<0.05)。结论 采用替米沙坦治疗2型糖尿病合并高血压患者，可以显著改善患者的胰岛素抵抗，提高患者血循环中APN含量，对减少患者远期并发症、改善患者的预后有益，值得临床关注。
[关键词] 2型糖尿病；高血压病；替米沙坦；胰岛素抵抗；脂联素
[中图分类号] R587.1 [文献标识码] B [文章编号] 1673-9701(2011)32-60-02
The Impact of Telmisartan on Insulin Resistance and Adiponection(APN) in Patients with Hypertension and Accompanied with Type 2 Diabetes
LI Yunchao WANG Bingjie ZHU Yingbin
Department of Endocrinology，Wencheng County People's Hospital in Zhejiang Province，Wencheng 325300，China
[Abstract] Objective To investigate the impact of telmisartan on insulin resistance and adiponection(APN) in those patients with hypertension and accompanied with type 2 diabetes. Methods A total of 80 patients diagnosed with hypertension and type 2 diabetes were randomly divided into the telmisartan and control groups，with 40 cases in each group. Based on the oral glucose-lowering agents，telmisartan was added in the telmisartan group，while amlodipine was added in the control group. Results In all these patients，the blood pressure all decreased to 140/90mmHg after 10 weeks of treatment，while SBP and DBP had no significant changes between two groups(P>0.05). There was no significant difference of FBS，Fins，HOMA-IR， APN between two groups before treatment. The HOMA-IR in the telmisartan group decreased significantly than that of the control group(P<0.05)，while the APN in the peripheral blood was higher than that of the control group(P<0.05). Conclusion Telmisartan can improve insulin resistance significantly in patients with type 2 diabetes and hypertension，increase their APN in blood circulation，reduce their long-term complications，improve their prognosis thus worth clinical attention.
[Key words] Type 2 diabetes；Hypertension；Telmisartan；Insulin resistance；Adiponectin ......
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