美沙拉嗪缓释颗粒对溃疡性结肠炎患者血清IL-6、TNF-α影响机制的研究(1)
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[摘要] 目的 探讨美沙拉嗪缓释颗粒对溃疡性结肠炎患者的疗效，以及对血清白介素(IL-6)、肿瘤坏死因子(TNF-α)影响机制的研究。方法 入院确诊的70例溃疡性结肠炎患者随机分为治疗组(美沙拉嗪缓释颗粒)和对照组(SASP)各35例，比较两组治疗前后肠镜变化、临床疗效及血清IL-6、TNF-α的变化情况。结果 治疗组的疗效优于对照组(P<0.01)。两组治疗后的IL-6、TNF-α较治疗前明显降低，P<0.01，t值分别为12.36，12.75，12.24，12.42，且治疗组的降低程度较对照组更明显，差异有统计学意义，t值分别为12.27，12.35，P<0.01。 结论 美沙拉嗪缓释颗粒治疗溃疡性结肠炎可显著提高临床疗效，考虑可能是通过降低IL-6水平、TNF-α而起作用的，其具体机制尚有待进一步研究。
[关键词] 溃疡性结肠炎；美沙拉嗪缓释颗粒；血清白介素(IL-6)；肿瘤坏死因子(TNF-α)
[中图分类号] R574.1 [文献标识码] B [文章编号] 1673-9701(2011)36-34-02
The Study of the Mechanism of Mesalazine Release Granules on Serum IL-6，TNF-α in Ulcerative Colitis Patients
CHEN Qiangmei
Zhejiang Province Tonglu Country MCH，Tonglu 311500，China
[Abstract] Objective To investigate the efficacy of mesalazine on the of ulcerative colitis，and to explore the mechanism of serum interleukin(IL-6)， tumor necrosis factor(TNF-α) in UC. Methods All of 70 patients with ulcerative colitis were randomly divided into treatment groups(mesalazine slow-release granules) and the control group(SASP) two groups，each 35 cases，endoscopic changes and clinical efficacy and serum IL-6，TNF-α changes were compared before and after treatment. Results The efficacy of the treatment group was better than the control group(P<0.01). After treatment， the levels of IL-6 was significantly lower than before treatment，the treatment group decreased level of serum IL-6 was more significantly than the control group， the difference was statistically significant，P<0.01. Conclusion Mesalazine slowes release granules for ulcerative colitis，and it can significantly improve the clinical efficacy，consideration may be by reducing the level of IL-6 play a role，the specific mechanism remains to be further studied.
[Key words] Ulcerative colitis；Mesalazine slow release granules；Serum interleukin(IL-6)；Tumor necrosis factor(TNF-α)
溃疡性结肠炎是消化系的常见病、多发病，近年来，其发病率逐年升高，目前临床治疗溃疡性结肠炎的方法较多，且疗效报道不一[1]。研究发现，白介素(IL)在溃疡性结肠炎(UC)的发病中起了重要作用，其中IL-6分泌增加影响肠上皮细胞电解质分泌紊乱，介导了其他炎性细胞发生炎性反应[2]。本研究旨在探讨美沙拉嗪缓释颗粒对溃疡性结肠炎患者的疗效，以及对血清白介素(IL-6)、TNF-α的影响机制，现报道如下。
1 资料与方法
1.1一般资料
我院2009年2月～2010年2月入院确诊的70例溃疡性结肠炎患者，符合 2000年全国炎症性肠病学术会议修改的溃疡性结肠炎诊断标准[3]，排除有患有严重心、肝、肾等重要脏器疾病或血液、内分泌系统疾病患者、消化道肿瘤、对水杨酸类药物过敏者及精神障碍疾病者 ......
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