老年男性下肢动脉硬化与骨密度的相关性研究(1)
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[摘要] 目的 探讨老年男性原发性骨质疏松(osteoporosis，OP)与下肢动脉硬化之间的关系。 方法 采用彩超检测130例老年男性下肢动脉血管壁内膜厚度、血管内径、斑块、血流情况，按病变严重程度分为无病变组，轻度病变组，中重度病变组。测定血脂、骨代谢指标、采用双能X线吸收仪(dual-energy X-ray absorptiometry，DXA)测定骨密度(bone mineral density，BMD)，比较三组间的骨密度、骨代谢指标、血脂差异。 结果 无病变组骨密度、血清骨碱性磷酸酶均高于轻度病变组和中重度病变组，无病变组总胆固醇及低密度脂蛋白低于中重度病变组，无病变组高密度脂蛋白、甘油三脂高于中重度病变组。 结论 老年男性下肢动脉硬化是骨密度下降的危险因素，脂代谢参与两者发病。
[关键词] 骨质疏松；动脉硬化；骨密度
[中图分类号] R580 [文献标识码] B [文章编号] 1673-9701(2012)03-0056-03
The relationship between arteriosclerosis of lower extremity and osteoporosis in elderly male patients
YAO Qi1 YU Jingbo1 ZHANG Xiuzhen2
1.Senior Cadres Ward, Ningbo NO.1 Hospital in Zhejiang Province, Ningbo 315010, China; 2.Department of Endocrinology and Metabolism, Affiliated Tongji Hospital to Shanghai Tongji University, Shanghai 210000, China
[Abstract] Objective To discuss the relationship between osteoporosis and arteriosclerosis of lower-extremity in elderly male patients. Methods The arterial wall endometrial thickness, luminal diameter, plaque and blood flow of lower -extremity was dectected by ultrasound in 130 male elderly patients. And the patients were divided into 3 groups(non-arteriosclerosis group, mild group, moderate/severe group) according to the severity of lower-extremity artery disease, which the blood lipid and bone metabolic parameters were measured. Then the bone mineral density (Bone mineral density, BMD) was measured by dual energy X ray absorptiometry (DXA, GE Lunar, US). At last, we compared the difference of the BMD, bone metabolic parameters, and serum lipid in these 3 groups. Results In the non-arteriosclerosis group, the BMD and bone alkaline phosphatase(BALP) were both higher than other 2 groups(mild group and moderate/severe group), the total cholesterol and low density lipoprotein(LDL) were lower than the moderate /severe group, and the High density lipoprotein(HDL) and triglycerides were higher than moderate/severe group. Conclusion The atherosclerosis of lower extremity is one of the risk factor in bone mass decrease in elderly male patients, and lipid metabolism may be involved in these two diseases ......
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