化瘀杀胚汤联合米非司酮治疗异位妊娠的疗效观察(1)
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[摘要] 目的 观察中药化瘀杀胚汤联合米非司酮治疗异位妊娠的临床疗效和安全性。 方法 90例异位妊娠患者随机分为两组：治疗组45例予口服米非司酮200 mg/d，连用3 d，并加用中药自拟化瘀杀胚汤；对照组45例单用米非司酮200 mg/d，连用3 d，监测血β-HCG水平及包块变化情况，记录β-HCG降至正常及包块消失所需时间。 结果 治疗组成功率(84.4%)显著高于对照组(62.2%)， 差异有统计学意义(P < 0.05)；治疗组β-HCG复常时间短于对照组(P < 0.05)；治疗组包块消失时间快于对照组(P < 0.05)，研究中未发现与药物治疗有关的不良反应。 结论 化瘀杀胚汤、米非司酮均能有效地治疗异位妊娠，两者合用有协同作用，治疗异位妊娠疗效比单用米非司酮好。
[关键词] 异位妊娠；化瘀杀胚汤；米非司酮；β-HCG
[中图分类号] R271.4 [文献标识码] B [文章编号] 1673-9701(2012)03-0073-02
Clinical observation on therapeutic effects of combination of traditional Chinese and medicine for trearment for eclopic pregnancy
LIU Yingnan WANG Junli
Department of Gynecology, Women and chidren hospital of Ningbo municipality, Ningbo 315010, China
[Abstract] Objective To explore the clinical effects of mifepristone combined with huayu shapei prescription in the treatment of eclopic pregnancy. Methods All of 90 patienets with eclopic pregnancyecl were randomly divided into two groups：the treatment and group and control group.The combined treatment group was treated with huayu shapei prescription and mifepristone.The control group was treated with mifepristone.The time of β-HCG reducing to normal and masses disapearqnce was obserned. Results The effective rate in the treatment group was 84.5%, and it was higher than the control group (62.50%) (P < 0.05). The time of β-HCG reducing to normal in treatment group was higher than the control group (P < 0.05). The time masses disapearqnce in treatment group was speed than the control group (P < 0.05). There were no adverse drug reactions resulting from using drugs in the research. Conclusion Huayu shapei prescription and mifepristone therapy may effectively treat eclopic pregnancy.The effect of combined using on eclopic pregnancy is superior to that of simple mifepristone.
[Key words] Eclopic pregnancy;Huayu shapei prescription;Mifepristone;β-HCG
异位妊娠是妇科常见急腹症，是早期孕妇死亡的主要病因[1]，各种原因致使其发病呈现升高趋势，但伴随诊断与监测水平的提高，异位妊娠早期诊断率大大地提升，为其保守治疗创造了时机。传统保守治疗常用米非司酮、甲氨喋呤，两者均对胚胎具有杀灭作用，但后者往往会带来严重的不良反应。我院随机使用自拟化瘀杀胚汤联合米非司酮治疗异位妊娠45例，同时与单用米非司酮进行对比，现报道如下。
1 资料与方法
1.1 临床资料
随机选择2007年6月～2010年5月期间我院收治的异位妊娠患者90例，年龄20～41岁，平均(28.45±5.67)岁，停经时间平均(42.87±9.39) d，通过临床症状、体征、血β人体绒毛膜促性腺激素(β human chorionic gonadotrop ......
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