氯吡格雷对不稳定型心绞痛患者血浆炎症因子的影响(1)
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[摘要] 目的 探讨氯吡格雷对不稳定型心绞痛患者血浆炎症因子的影响及疗效观察。 方法 选择72例不稳定型心绞痛患者，随机分为观察组和对照组。两组患者均按不稳定型心绞痛的治疗方案进行治疗，观察组在此基础上加用氯吡格雷75 mg，每天1次，连用2周。 结果 治疗2周后，两组患者血浆TNF-α、MMP-9和IL-6水平均较治疗前明显下降(P < 0.05或P < 0.01)，且观察组下降的幅度较对照组更明显(P < 0.05)。观察组控制心绞痛的总有效率明显优于对照组(χ2=5.67，P < 0.05)。两组治疗期间均无明显的不良反应。 结论 氯吡格雷治疗不稳定型心绞痛是一种安全、有效的方法，其作用机制与其改善血管内斑块的炎症反应有关。
[关键词] 氯吡格雷；不稳定型心绞痛；炎症因子
[中图分类号] R541.4 [文献标识码] B [文章编号] 1673-9701(2012)03-0075-02
Effect of clopisogrel sulfate on the levels of inflammatory factors in patients with unstable angina pectoris
WANG Zhenhai
Department of Emergency, the First People's Hospital of Taizhou in Zhejiang Province, Taizhou 318020, China
[Abstract] Objective To observe the effect of clopidogrel on levels of inflammatory factors in patients with unstable angina pectoris (UAP) and the clinic effect. Methods All of 72 patients who were diagnosed as UAP were divided randomly into two groups as observation group and control group. All patients in both groups received the routine medicine treatment, and the observation group got extra treatment as taking colposogrel sulfate 75 mg orally once a day for two weeks. Results The levels of INF-α, MMP-9 and IL-6 decreased significantly in either group at two weeks after treatment (P < 0.05 or P < 0.01), and the reducing was more obvious in observation group (P < 0.05). During the treatment period, the total effective rate for angina pectoris of observation group was significantly higher than that of control group (χ2=5.67, P < 0.05), and no obvious adverse reaction was observed in either group. Conclusion Clopisogrel sulfate shows safe and effective on patients with UAP. Maybe the mechanism relates to that clopisogrel sulfate has anti-inflammatory effect, and can improve blood vessel plaque inflammation.
[Key words] Clopisogrel sulfate; Unstable angina pectoris; Inflammatory factor
近年来研究发现炎症因子在不稳定型心绞痛的发生和发展中起重要的作用，其中肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-9(MMP-9)和白细胞介素-6(IL-6)是目前研究较多、较活跃的炎症因子[1]。氯吡格雷是一种新型抗血小板药物，治疗不稳定型心绞痛的疗效肯定，但有关氯吡格雷对不稳定型心绞痛患者血浆炎症因子的影响国内外报道较少[2]。本研究旨在观察并探讨氯吡格雷治疗不稳定型心绞痛的疗效及对血浆炎症细胞因子TNF-α、MMP-9和IL-6水平的影响，现报道如下。
1 资料与方法
1.1 研究对象
选择2005年1月～2011年6月在我院住院治疗的不稳定型心绞痛患者72例 ......
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