PELANC结合bFGF治疗手部小面积皮肤缺损(1)
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[摘要] 目的 探讨采用PELANC结合bFGF治疗手部小面积皮肤缺损的效果。 方法 将2010年1月～2011年8月我院收治的52例手部小面积皮肤缺损患者，根据治疗方法的不同随机分为观察组和对照组各26例，观察组26例采用双层人工真皮皮能快愈敷料(PELANC)结合贝复济(bFGF)治疗，对照组仅应用bFGF，术后评估两组手部皮肤存活情况、皮片外观及供皮区愈合情况，随访近、远期手部功能恢复情况。 结果 观察组手部植皮区全部存活皮片，供皮区仅有轻微色素沉淀，外观与功能具佳。观察组术后治疗1个月和术后6个月的优良率均明显高于对照组，差异有统计学意义(P < 0.05)。观察组创面覆盖速度较对照组明显提高，差异有统计学意义，且观察组的病程短，感染率低，两组上述观察指标分别比较，差异有统计学意义(P < 0.05)。 结论 PELANC结合bFGF治疗手部小面积皮肤缺损能够兼顾手的功能和美观。
[关键词] PELANC； bFGF；手部；小面积皮肤缺损
[中图分类号] R658.2 [文献标识码] B [文章编号] 1673-9701(2012)06-0036-03
Clinical application of PELANC combined with bFGF in treatment of small area skin defects of hand
LIAO Hai CAI Junhui
Department of Hand Surgery, the Third Affiliated Hospital of Wenzhou Medical Collage, Rui'an People's Hospital Rui'an 325200, China
[Abstract] Objective To evaluate the effects of PELANC and bFGF on treatment of small area skin defects of hand. Methods Retrospective analysis of 52 cases of small area skin defects of hand in hospital, from January 2010 to August 2011, treatment with PELANC and bFGF, postoperative evaluation of the hand skin survival,skin appearance and healing of donor sites, follow-up of short and long term recovery of hand function. Results All hand skin graft survival, donor site with only a slight pigmentation, the appearance and function are satisfactory. Observation group after 1 month of treatment and after 6 months were significantly higher than the fine, the difference was significant (P < 0.05). Covering the wound observation group than the control group was significantly faster, the difference was significant, and the observation group with a short course of the infection rate is low, these two indicators were observed, the difference was significant (P<0.05).Conclusion PELANC and bFGF can take into account the small area of skin defect of hand functional and aesthetic.
[Key words] PELANC； bFGF；Hand； Small area skin defects
随着沿海地区经济的发展，手外伤特别是手部小面积皮肤缺损的患者越来越多，迫切要求使用新材料和新方法来提高治疗效果。1980年Yannas[1]等研制出一种特殊的双层人工真皮皮能快愈敷料(PELNAC)用于暂时代替缺损的真皮，促进肉芽的生长，可以形成用于二次植入表皮的基底。尹刚等[2]通过碱性成纤维细胞因子对真皮下血管网皮瓣成活影响的实验研究，发现bFGF(贝复济)能够通过促进皮瓣远段血运重建 ......
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