2型糖尿病肾病患者血小板及血脂水平的变化(1)
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[摘要] 目的 对血脂及血小板参数进行检测,探讨其在2型糖尿病肾病患者中的检测意义。 方法 观察组为在我院治疗的2型糖尿病肾病患者76例,T2DM组为2型糖尿病患者76例,但是其均没有并发症,对照组为健康人员76例,对三组研究对象的血脂水平及血小板参数进行检测,三组间进行比较。 结果 与对照组及T2DM组进行比较,甘油三酯和胆固醇等血脂水平在观察组中的检测数值均明显较高,差异具有统计学意义(P < 0.05),血小板平均体积、血小板体积分布宽度及血小板压积等血小板参数也明显较高,而血小板计数均明显较低,差异具有统计学意义(P < 0.05)。 结论 对糖尿病肾病进行血脂及血小板参数的检测对疾病的早期诊断和病情分析都具有非常重要的临床意义。
[关键词] 糖尿病肾病;甘油三酯;总胆固醇;血小板计数;平均血小板体积
[中图分类号] R446.11 [文献标识码] B [文章编号] 1673-9701(2012)06-0045-02
The clinical significance of platelet and lipid levels in patients with type 2 diabetic nephropathy
WANG Kai
Department of Laboratory, Zhejiang Province Shaoxing People's Hospital, Shaoxing 312000, China
[Abstract] Objective To detect blood lipids and platelet parameters and explore the detection significance in patients with type 2 diabetic nephropathy. Methods All of 76 patients with type 2 diabetic nephropathy in study group were selected from our hospital, 76 patients with type 2 diabetes in T2DM group were selected, but they had no complications, 76 health personnel in the control group were selected. Lipid levels and platelet parameters in three groups were tested and compared. Results Compared with T2DM group and control group, the levels of triglycerides and cholesterol in the study group were significantly higher (P < 0.05), mean platelet volume, platelet volume distribution width, platelet hematocrit were significantly higher, and platelet counts was significantly lower (P < 0.05). Conclusion Diabetic nephropathy and platelet lipid parameters for the detection of disease, early diagnosis and analysis of the patient's condition has very important clinical significance.
[Key words] Diabetic nephropathy; Triglycerides; Total cholesterol; Platelet count; Mean platelet volume
在糖尿病(DM)患者疾病的发生发展过程中糖尿病肾病(DN)为一种严重的并发症,临床上较为常见,但是临床对于糖尿病肾病患者的发病机制还不能完全阐明。糖尿病肾病是一种全身微血管病变,除了遗传因素以外,在糖尿病肾病发病的过程中代谢因素也起着重要的作用。糖尿病肾病患者的主要临床特征表现为蛋白尿、高血压,还表现为不断下降的肾功能[1]。在糖尿病患者中如果不采取积极有效的治疗措施,大约有30%~40%会发展为DN患者,并且此类患者的血脂常常出现代谢失衡,而作为一个疾病的伴发症状出现。本研究对糖尿病肾病患者、糖尿病但没有并发症患者及健康人员的血脂与血小板进行了测定,并在组间进行了比较,拟探讨其在糖尿病肾病患者疾病中的变化及临床意义,现将结果报道如下。
1 资料与方法
1.1 一般资料
观察组为在我院治疗的2型糖尿病肾病患者76例,其中男35例,女41例,年龄33~81岁,平均(65.7±11.2)岁。入院后所有观察组的患者均进行了24 h尿白蛋白检查,对UAER(24 h尿白蛋白排泄率)进行测定,糖尿病肾病患者确诊的依据为UREA的检测值超过20 μg/min ......
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