阿托伐他汀钙对冠心病心力衰竭患者心功能的影响(1)
 |
| 第1页 |
参见附件。
[摘要] 目的 探讨不同剂量阿托伐他汀钙对冠心病心力衰竭患者心功能和预后的影响。 方法 将我院收治的冠心病慢性心力衰竭患者84例随机分为研究组和对照组各42例，对照组给予慢性心力衰竭的常规治疗加用阿托伐他汀钙20mg/d，研究组患者在常规治疗的基础上加用阿托伐他钙40 mg/d口服，患者出院后坚持服用，并随访1年，比较两组患者左室射血分数(LVEF)、每搏输出量(SV)、每分输出量(CO)、心脏左室舒张未内径(LVDD)、脑钠肽(NT-ProBNP)以及1年内患者平均住院频度、住院总日数和病死率。 结果 治疗后两组患者LVEF、SV、CO明显增加，研究组患者各项指标优于对照组患者(P < 0.05)；两组患者LVDD及NT-ProBNP明显减低，研究组指标改善较对照组明显。随访期间两组患者住院频数和住院总日数无统计学意义(P > 0.05)，研究组患者死亡率低于对照组，差异有统计学意义(P < 0.05)。 结论 大剂量阿托伐他汀钙较常规剂量辅助治疗冠心病心力衰竭可以明显改善患者心功能，提高患者预后。
[关键词] 冠心病；心力衰竭；阿托伐他汀；预后
[中图分类号] R541.4 [文献标识码] B [文章编号] 1673-9701(2012)06-0066-02
The heart function of atorvastatin calcium treatment for coronary patients with heart failure
JIANG Zhiping1 LIU Shouxiang2
1.Department of Cardiology, Northern Part of Guangdong People's Hospital in Guangdong Province, Shaoguan 512026, China; 2.Department of Emergency, Shaoguan City TCM Hospital in Guangdong Province, Shaoguan 512026, China
[Abstract] Objective To investigate the prognosis and heart function of atorvastatin calcium in treatment with two different doses for coronary patients with heart failure. Methods Eighty-four patients with chronic heart failure coronary heart disease were randomly divided into study group and control group, 42 cases in each group, conventional treatment with atorvastatin calcium 20 mg/d was given for the patients in control group and atorvastatin calcium was added in study group 40mg/d, compared two groups of patients with left ventricular ejection fraction (LVEF), stroke volume (SV), each sub-output(CO), left ventricular end-diastolic heart diameter (LVDD), N-Terminal Pro-Brain natriuretic peptide (NT-ProBNP) and one year with an average frequency of hospitalization, the total number of days of hospitalization and mortality. Results After treatment, LVEF, SV, CO increased and LVDD, NT-proBNP lowed significantly, the study group patients were better than control patients (P < 0.05); Two groups of patients hospitalized during follow-up frequency and total number of days hospitalized was no significant difference (P > 0 ......
您现在查看是摘要介绍页，详见PDF附件(2088kb)。