阿托伐他汀钙对冠心病心力衰竭患者心功能的影响(1)
 |
| 第1页 |
参见附件。
[摘要] 目的 探讨不同剂量阿托伐他汀钙对冠心病心力衰竭患者心功能和预后的影响。 方法 将我院收治的冠心病慢性心力衰竭患者84例随机分为研究组和对照组各42例，对照组给予慢性心力衰竭的常规治疗加用阿托伐他汀钙20mg/d，研究组患者在常规治疗的基础上加用阿托伐他钙40 mg/d口服，患者出院后坚持服用，并随访1年，比较两组患者左室射血分数(LVEF)、每搏输出量(SV)、每分输出量(CO)、心脏左室舒张未内径(LVDD)、脑钠肽(NT-ProBNP)以及1年内患者平均住院频度、住院总日数和病死率。 结果 治疗后两组患者LVEF、SV、CO明显增加，研究组患者各项指标优于对照组患者(P < 0.05)；两组患者LVDD及NT-ProBNP明显减低，研究组指标改善较对照组明显。随访期间两组患者住院频数和住院总日数无统计学意义(P > 0.05)，研究组患者死亡率低于对照组，差异有统计学意义(P < 0.05)。 结论 大剂量阿托伐他汀钙较常规剂量辅助治疗冠心病心力衰竭可以明显改善患者心功能，提高患者预后。
[关键词] 冠心病；心力衰竭；阿托伐他汀；预后
[中图分类号] R541.4 [文献标识码] B [文章编号] 1673-9701(2012)06-0066-02
The heart function of atorvastatin calcium treatment for coronary patients with heart failure
JIANG Zhiping1 LIU Shouxiang2
1.Department of Cardiology, Northern Part of Guangdong People's Hospital in Guangdong Province, Shaoguan 512026, China; 2.Department of Emergency, Shaoguan City TCM Hospital in Guangdong Province, Shaoguan 512026, China
[Abstract] Objective To investigate the prognosis and heart function of atorvastatin calcium in treatment with two different doses for coronary patients with heart failure. Methods Eighty-four patients with chronic heart failure coronary heart disease were randomly divided into study group and control group, 42 cases in each group, conventional treatment with atorvastatin calcium 20 mg/d was given for the patients in control group and atorvastatin calcium was added in study group 40mg/d, compared two groups of patients with left ventricular ejection fraction (LVEF), stroke volume (SV), each sub-output(CO), left ventricular end-diastolic heart diameter (LVDD), N-Terminal Pro-Brain natriuretic peptide (NT-ProBNP) and one year with an average frequency of hospitalization, the total number of days of hospitalization and mortality. Results After treatment, LVEF, SV, CO increased and LVDD, NT-proBNP lowed significantly, the study group patients were better than control patients (P < 0.05); Two groups of patients hospitalized during follow-up frequency and total number of days hospitalized was no significant difference (P > 0 ......
您现在查看是摘要介绍页，详见PDF附件(2088kb)。
闂傚倸鍊搁崐鎼佸磹閸濄儮鍋撳鐓庡籍鐎规洘绻堥獮鎺楀籍閸ヮ灝鈥愁渻閵堝棗绗掗悗姘煎墰閳ь剚鑹鹃ˇ閬嶅焵椤掆偓缁犲秹宕曢柆宥呯疇閹兼惌鐓夌紞鏍煏閸繍妲归柣鎾存礋閺屻劌鈹戦崱妤佹婵犵鈧偨鍋㈤柟顔荤矙椤㈡稑顫濋鐐寸亷闁诲氦顫夊ú妯兼崲閸岀偛鐓″璺猴功閺嗭箓鏌涢妷銏℃珦婵℃煡顥撶槐鎾诲磼濮橆兘鍋撻幖浣哥柈妞ゆ牜鍋涢崹鍌滄喐閻楀牆绗氶柛瀣枑閵囧嫰寮介顫勃闂佺粯甯＄粻鏍蓟閺囩喓绠鹃柛顭戝枛婵酣姊虹拠鍙夊攭妞ゆ泦鍡楃倒闂備焦鎮堕崕鑽ゅ緤閼恒儲娅犻柟缁樺础瑜版帗鍋傞幖娣灩濞堟鎮楃憴鍕┛缂傚秳绶氶妴渚€寮崼婵堫槰濡炪倕绻愬ú銊х不閺屻儲鈷掑ù锝堟鐢盯鏌ｅΔ浣圭闁伙絿鍏橀、妤呭磼濠婂懎顦╅梻浣虹帛閸旓箓宕滃▎鎿冩晪閺夊牄鍔嶉崣蹇旀叏濡も偓濡鏅堕鐐寸厱闁绘ê寮堕崵鍥煛瀹€鈧崰鎾诲焵椤掍胶鈯曞畝锝嗗閺呭爼顢楁担铏圭槇闂侀€炲苯澧柟宄版嚇瀹曠兘顢樺☉娆戜簷闂傚倷绶氶埀顒傚仜閼活垱鏅舵导瀛樼厓鐟滄粓宕滃┑瀣剁稏濠㈣泛饪村ḿ鈺呮煏婵炲灝濡烽柛娆撶畺濮婄粯鎷呴崨濠傛殘闁汇埄鍨辩敮鎺曠亱濠电偞鍨惰彜闁哄妫冮弻鐔衡偓娑欋缚婵″洭鏌＄€ｎ偆澧甸柡灞炬礃缁绘盯宕归鐓庮潛闂備礁鎼崐鐢稿磻閹炬枼鏀介柣鎰摠缂嶆垿鏌涘顒夊剶闁硅櫕绻冮妶锝夊礃閵娧呮瀫闂備礁鎲￠崝姗€藟閸℃瑦鍠嗛柛鏇ㄥ墮椤庢挾绱撴担鍦槈妞ゆ垵妫涚槐鐐茬暆閸曨兘鎷洪梻鍌氱墛缁嬫帡鏁嶉弮鍫熺厵闁告垯鍊栫€氾拷
婵犵數濮甸鏍窗濡ゅ啯宕查柟鐗堟緲缁狀垶鏌ㄩ悤鍌涘 pdf闂傚倸鍊烽懗鑸电仚缂備浇顕ч悧鎾崇暦濠靛棭鍚嬪璺猴工閸ゆ垿姊虹捄銊ユ珢闁瑰嚖鎷� 闂傚倸鍊搁崐鎼佸磹缁嬫５娲偐鐠囪尙锛涢梺鐟板⒔缁垶宕戦敓鐘崇厸闁搞儲婀圭花濂告倵濮樼偓瀚� 5 缂傚倸鍊搁崐椋庣矆娓氣偓钘濆ù鐘差儏閸ㄥ倸霉閸忓吋缍戦柛銊ュ€块獮鏍庨鈧俊浠嬫煛閸滀礁澧撮柡灞剧洴椤㈡洟鏁愰崶鈺冩殼闂佹眹鍩勯崹杈ㄧ箾婵犲洤绠栫憸鐗堝笒缁犳稒銇勯弽鐢电ɑ缂傚秴鐗撳鐑樻姜閹峰苯鍘￠梺绋款儍閸婃洟鎮惧畡鎷旂喖鎼圭憴鍕暦闂備線鈧偛鑻晶顕€鏌嶇拠鑼у┑锛勫厴婵℃悂鏁愰崟顒傛綎闂傚倷绀侀幖顐⒚洪妸鈺佺；闁绘劕鎼壕褰掓煥閻曞倹瀚�婵犵數濮甸鏍闯椤栨粌绶ら柣锝呮湰瀹曟煡鏌熼悧鍫熺凡濡楀懏绻濋姀锝呯厫闁告梹娲熼幆灞轿旀担鍏哥盎闂佸搫绉查崝搴ㄥ箠娴ｈ櫣纾奸柕濠忛檮缁舵煡鎽堕悙鐑樼厸濠㈣泛顑呴婊勩亜閵夛妇鐭岄柟鎻掓憸閺侇噣顢欓挊澶樹紦10濠电姷鏁搁崑鐐哄垂閸洖绠归柍鍝勫€婚々鏌ユ煟閹邦剛浜柛娆撶畺濮婄粯鎷呴崨濠傛殘闁汇埄鍨兼禍顏堢嵁韫囨稒鏅搁柨鐕傛嫹闂傚倸鍊烽悞锔锯偓绗涘懐鐭欓柟娆¤娲、姗€濮€閻橀潧濮︽俊鐐€栫敮鎺楁晝閵壯€鍋撳鐐
闂傚倷绀侀幖顐﹀磹缁嬫５娲Ω閳哄倸浠ч梺缁樺灱婵倝宕戠€ｎ喗鐓曟い鎰╁€曢弸鎴犵磽瀹ヤ礁浜鹃梻浣筋嚙缁绘帡宕戦悢鐓庣；婵☆垵澹堟慨铏亜閹烘垵顏╅柛灞诲姂閺岋綁寮崒婊冪闂佸摜鍠庨悘婵嬫箒闂佹寧绻傚Λ娑㈡儗鐎ｎ偆绠鹃柣鎾虫捣婢ф稓绱掗崒姘毙ч柟顕呭枤閳ь剟娼ч幗婊埶囬鈧娲礂閼测晜鑿囬梺绋垮閻撯€崇暦閹存繍鍚嬮柛銉ｅ妼椤庢盯姊洪棃娑氬閻庢凹鍨崇划鍫⑩偓锝庡亝閸欏繑绻濋棃娑橆仼闁逞屽墯閻楃姴顕ｉ幖浣哥闁冲搫鍟犻弸鏍倵楠炲灝鍔氶柟铏姍瀵儼銇愰幒鎾充哗濠殿喗岣块崢褎绂嶅┑瀣厸濞达絼璀﹂弨浼存煏閸ャ劌濮嶇€殿喗娼欓～婵囨綇椤愩倗顔夋繝鐢靛О閸ㄥ綊鎮ラ姀銈呯闁诡垎鍕彃闂傚倷鑳舵灙缂佺粯鍔楃划鏃堟倻閽樺鐎梺绋跨灱閸嬬偤鍩涢幘缁樼厱婵炴垯鍨规禍浼存煕閵堝啫鐏查柡灞诲妼閳藉螣閼测晛濮版俊鐐€栧ú锕傚礈閻旂厧钃熼柛銉墻閺佸﹦绱撴担鐧镐緵闁稿鍔戝娲偡閹殿喗鎲奸梺缁橆殕缁挸顕ｉ锕€浼犻柕澶涚畱閻濇澘鈹戦悩缁樻锭妞ゆ垵鍊垮畷鎴﹀箻閹颁焦鍍甸柡澶婄墐閺呮稑顕ｉ妸鈺傗拺闁荤喐澹嗛幗鐘绘煕閵娿儱鏆辨顏冨嵆楠炲鏁傞懞銉︾彨闂佽绻掗崑鐐哄磿閹惰姤鍊跺璺衡姇瑜版帗鍋戦柍褜鍓熷畷婊冾潩鐠虹儤鐎悷婊呭鐢帞绮堥崱妞曞綊鎳栭埡鍕婂鏌涚€ｎ偅灏い顐ｇ箖濞煎繘鍩℃担鍝ュ摋闂傚倷绀侀幉锟犳嚌妤ｅ啫绀勯柣锝呮湰椤洘绻濋棃娑欐悙妞ゆ洝椴搁幈銊ノ熸径绋挎儓閻熸粍婢橀惌鍌炲蓟濞戞鏃堝焵椤掑嫬鐤柛褎顨嗛崕宥夋煏韫囧鈧洜绮婚弽顓熺厪濠电倯鍐伀闁哄棛濮电换娑欐綇閸撗吷戠紓渚囧枛閻倿鐛弽顒夋Ъ缂備礁鍊圭敮妤呭箚閺冨牆顫呴柍鈺佸暙椤忔壆绱撻崒姘偓鎼佸疮椤栫偛鍨傜憸鐗堝笚閸嬬喐銇勯弽顐粶缂佲偓閸℃稒鐓熸俊顖濆亹鐢盯鏌ｅ┑鍫濇灈闁哄本娲熷畷閬嶎敇閻斿浼�