[摘要] 基底细胞样型乳腺癌是一组具有肌上皮/基底细胞免疫表型特征的乳腺癌，其预后通常较差。而DNA拓扑异构酶Ⅱ (topoisomeraseⅡ，TopoⅡ)是DNA代谢过程中重要核酶，其可作为蒽环类药物疗效及乳腺癌的预后指标。且亦有研究发现Ki67抗原与乳腺癌淋巴结转移关系密切，检测Ki67抗原亦可成为判断乳腺癌预后的重要指标。因此，本文就TopoⅡ及Ki67及在基底细胞样乳腺癌中作用展开综述。

    [关键词] DNA拓扑异构酶Ⅱ；Ki67抗原；基底细胞样型乳腺癌

    [中图分类号] R614.3；R971+.12[文献标识码] A[文章编号] 1673-9701(2012)10-0032-03

    The roles of Topo Ⅱ and Ki67 in basal-like breast cancer

    HUANG Yajuan1 YU Xiaohong2 DU Feng1

    1.Department of Galactophore, Maternal and Child Care Service Centre of Jiangxi Province, Nanchang 330006, China； 2. Department of Pathology, Maternal and Child Care Service Centre of Jiangxi Province, Nanchang 330006, China

    [Abstract] Basal-like breast cancer is a group of myoepithelial / basal cell immune phenotype of breast cancer ......