肝内胆管细胞癌危险因素及发病机制研究(1)
[摘要] 目的 探讨肝内胆管细胞癌(ICC)危险因素及发病机制。 方法 102例ICC患者为病例组，200例无肿瘤体检者为对照组，对比两组ICC相关因素；并将病例组按血清HBsAg表达分组，对比两组临床病理学特征。 结果 病例组和对照组之间血清HBsAg阳性、HBV相关性肝硬化、酒精性肝硬化、其他原因肝硬化、肝内胆管结石、胆总管结石及肝吸虫病检出率之间有统计学意义(P < 0.05)。HBV相关性肝硬化、酒精性肝硬化、肝内胆管结石、其他原因肝硬化、血清HBsAg阳性及肝吸虫病与ICC密切相关(P < 0.05)。血清HBsAg阳性组和血清HBsAg阴性组年龄、性别比、AFP水平、CA19-9水平、肿瘤位置、组织学肝脏炎症、肝硬化、肿瘤胞膜、肿瘤分化、微血管侵犯、神经侵犯及淋巴结转移之间有统计学意义(P < 0.05)。 结论 HBV感染与ICC密切相关，是主要的危险因素，HBV感染导致的长期炎症可能参与ICC发生的机制。
[关键词] 肝内胆管细胞癌；危险因素；病例对照研究；乙型肝炎病毒
, 百拇医药
[中图分类号] R735.8 [文献标识码] B [文章编号] 1673-9701(2012)16-0075-03
Risk factors and pathogenesis of intrahepatic cholangiocarcinoma
WANG Xiaoping
Second Surgery, People''s Hospital of Shengzhou City in Zhejiang Province, Shengzhou 312400 ,China
[Abstract] Objective To investigate the intrahepatic cholangiocarcinoma (ICC), risk factors and pathogenesis. Methods A total of 102 cases of ICC patients as case group, 200 cases of tumor-free physical examination for the control group, compared two groups of ICC related factors; and the case group according to the group of HBsAg expression, compared to two sets of clinical and pathological features. Results Between case and control groups, serum HBsAg positive, HBV-related cirrhosis, alcoholic cirrhosis, other causes cirrhosis of the liver and intrahepatic bile duct stones, common bile duct stones and liver fluke disease detection rates were significantly different between the (P < 0.05). HBV-related cirrhosis, alcoholic cirrhosis of the liver and intrahepatic bile duct stones, and other causes cirrhosis of the liver, serum HBsAg positive for liver fluke disease and ICC closely related (P < 0.05). Serum HBsAg positive group, and serum HBsAg-negative group, age, sex ratio, the level of AFP, CA19-9 level, tumor location, histological inflammation of the liver, cirrhosis of the liver, the tumor cell membrane, tumor differentiation and microvascular invasion, perineural invasion, and lymph node metastasis there are significant differences (P < 0.05). Conclusion HBV infection is closely related to the ICC, is the main risk factors for HBV infection caused by long-term inflammation may be involved in the ICC mechanism.
[Key words] Intrahepatic cholangiocarcinoma;Risk factors; Case-control study; Hepatitis B virus
肝内胆管细胞癌(intrahepatic cholangiocarcinoma，ICC)是来自肝内二级分支以下肝内胆管上皮细胞恶性肿瘤，发病率呈上升趋势，但其病因及发病机制尚未明确。由于地区差异，其相关因素研究结果亦存在明显差异。西方国家研究认为原发性硬化性胆管炎是ICC的主要危险因素，而在我国原发性硬化性胆管炎的发病率则仅约为7/10万[1]。本研究通过病例对照研究分析我国ICC的危险因素，并对其发病机制进行初步探讨。, http://www.100md.com(王小平)
[关键词] 肝内胆管细胞癌；危险因素；病例对照研究；乙型肝炎病毒
, 百拇医药
[中图分类号] R735.8 [文献标识码] B [文章编号] 1673-9701(2012)16-0075-03
Risk factors and pathogenesis of intrahepatic cholangiocarcinoma
WANG Xiaoping
Second Surgery, People''s Hospital of Shengzhou City in Zhejiang Province, Shengzhou 312400 ,China
[Abstract] Objective To investigate the intrahepatic cholangiocarcinoma (ICC), risk factors and pathogenesis. Methods A total of 102 cases of ICC patients as case group, 200 cases of tumor-free physical examination for the control group, compared two groups of ICC related factors; and the case group according to the group of HBsAg expression, compared to two sets of clinical and pathological features. Results Between case and control groups, serum HBsAg positive, HBV-related cirrhosis, alcoholic cirrhosis, other causes cirrhosis of the liver and intrahepatic bile duct stones, common bile duct stones and liver fluke disease detection rates were significantly different between the (P < 0.05). HBV-related cirrhosis, alcoholic cirrhosis of the liver and intrahepatic bile duct stones, and other causes cirrhosis of the liver, serum HBsAg positive for liver fluke disease and ICC closely related (P < 0.05). Serum HBsAg positive group, and serum HBsAg-negative group, age, sex ratio, the level of AFP, CA19-9 level, tumor location, histological inflammation of the liver, cirrhosis of the liver, the tumor cell membrane, tumor differentiation and microvascular invasion, perineural invasion, and lymph node metastasis there are significant differences (P < 0.05). Conclusion HBV infection is closely related to the ICC, is the main risk factors for HBV infection caused by long-term inflammation may be involved in the ICC mechanism.
[Key words] Intrahepatic cholangiocarcinoma;Risk factors; Case-control study; Hepatitis B virus
肝内胆管细胞癌(intrahepatic cholangiocarcinoma，ICC)是来自肝内二级分支以下肝内胆管上皮细胞恶性肿瘤，发病率呈上升趋势，但其病因及发病机制尚未明确。由于地区差异，其相关因素研究结果亦存在明显差异。西方国家研究认为原发性硬化性胆管炎是ICC的主要危险因素，而在我国原发性硬化性胆管炎的发病率则仅约为7/10万[1]。本研究通过病例对照研究分析我国ICC的危险因素，并对其发病机制进行初步探讨。, http://www.100md.com(王小平)