肝细胞特异性对比剂Gd-EOB-DTPA在肝转移瘤MRI诊断中的应用(1)
[摘要] 目的 探讨肝细胞特异性对比剂Gd-EOB-DTPA在肝转移瘤MRI检出、诊断与鉴别诊断中的价值。 方法 收集我院2010年6月～2011年10月经临床、影像证实或高度怀疑的肝转移瘤20例患者，选取8例注射Gd-EOB-DTPA行MRI动态增强扫描及肝细胞特异期扫描，其中6例患者1个月内同时进行了螺旋CT增强扫描；12例注射普通对比剂Gd-DTPA，行MRI动态增强扫描，综合分析两项对比剂MRI增强扫描和CT增强扫描成像特征。 结果 MRI检查20例患者共检测到病灶83个，其中在动脉期、门脉期和平衡期发现病灶78个；8例注射Gd-EOB-DTPA患者在肝细胞特异期发现病灶55个，其中5个病灶在动态期(即常规三期扫描)未显示；6例患者同期行全肝螺旋CT增强扫描发现病灶31个，对比注射Gd-EOB-DTPA增强MRI扫描少发现8个病灶。 结论 肝细胞特异性对比剂Gd-EOB-DTPA由于具有双期特性对于病灶的数量、分布、边界有更清楚的显示，在MRI动态增强全肝扫描中更有利于肝脏转移瘤的检出和定性诊断。
[关键词] 肝细胞特异性对比剂；磁共振成像；转移性肿瘤；肝
, 百拇医药
[中图分类号] R735.7；R73-37 [文献标识码] B [文章编号] 1673-9701(2012)16-0094-02
Apllication of hepatocyte-specific contrast agent Gd-EOB-DTPA in MRI diagnosis of liver metastases
XUAN Haobo ZHU Yueming SHEN Jian LI Fengqi QIAN Haifeng
Department of Radiology， Huzhou Central Hospital in Zhejiang Province, Huzhou 313000， China
[Abstract] Objective To investigate the Hepatocyte-specific contrast agent (Gd-EOB-DTPA) in liver metastases MRI detected value in the diagnosis and differential diagnosis. Methods Twenty patients were collected from June 2010 to October 2011, which were clinical,imaging confirmed or highly suspected liver metastases. Eight cases were selected to inject Gd-EOB-DTPA in dynamic contrast-enhanced MRI scan and Hepatocyte-specific scan, while 6 cases had spiral CT scan at the same time. 12 cases were inject Gd-DTPA MRI in dynamic contrast-enhanced scan, compare with the two contrast agent enhanced MRI and enhanced CT imaging characteristics. Results Eighty-three lesions were detected in 20 cases with MRI scan, 78 of which is found in the arterial phase, portal phase, and the balance phase. 55 lesions were found in the Hepatocyte-specific phase of 8 cases with injected Gd-EOB-DTPA, which 5 lesions in the dynamic phase (the conventional three scan) is not displayed. 6 cases with whole liver enhanced spiral CT scan revealed lesions in 31, contrast injection of Gd-EOB-DTPA enhanced MRI scans less found 8 lesions. Conclusion The hepatocyte-specific contrast agent Gd-EOB-DTPA in MRI dynamic enhancement is more conducive to the liver metastases detection and diagnosis.
, 百拇医药
[Key words] Hepatocyte-specific contrast agent; MRI; Metastasis;Liver
肝转移性肿瘤的早期诊断主要依赖于影像学检查，肝脏MR动态增强检查已经成为一种常用的临床诊断及鉴别诊断肝脏病变的有效方法，肝转移灶特别是<1.0 cm的转移灶的检出、分布和诊断对于临床诊断、治疗有着重要的意义。本文通过肝细胞特异性对比剂Gd-EOB-DTPA结合MRI动态增强对肝转移瘤全肝扫描进行分析诊断，旨在探讨肝细胞特异性对比剂在提高肝转移瘤MRI检出率和诊断率中的应用价值。
1 资料与方法
1.1 一般资料
收集我院2010年6月～2011年10月经临床、影像证实或高度怀疑的肝转移瘤20例患者行上腹部磁共振(MRI)检查。男14例，女6例，年龄41～65岁，平均年龄53岁。其中原发肿瘤为直结肠癌9例，胰腺癌4例，肺癌1例，胃癌4例，宫颈癌和乳腺癌各1例。合并肝囊肿3例，合并肝血管瘤2例。所有病例原发肿瘤均经临床及综合影像分析确诊或病理证实。其中6例患者(2例胃癌，2例结肠癌，1例胰腺癌，1例食管癌)在1个月内同时进行了静脉注射Gd-EOB-DTPA增强 MRI动态扫描和螺旋CT增强扫描。, 百拇医药(宣浩波 祝跃明 沈健 李凤琪 钱海峰)
[关键词] 肝细胞特异性对比剂；磁共振成像；转移性肿瘤；肝
, 百拇医药
[中图分类号] R735.7；R73-37 [文献标识码] B [文章编号] 1673-9701(2012)16-0094-02
Apllication of hepatocyte-specific contrast agent Gd-EOB-DTPA in MRI diagnosis of liver metastases
XUAN Haobo ZHU Yueming SHEN Jian LI Fengqi QIAN Haifeng
Department of Radiology， Huzhou Central Hospital in Zhejiang Province, Huzhou 313000， China
[Abstract] Objective To investigate the Hepatocyte-specific contrast agent (Gd-EOB-DTPA) in liver metastases MRI detected value in the diagnosis and differential diagnosis. Methods Twenty patients were collected from June 2010 to October 2011, which were clinical,imaging confirmed or highly suspected liver metastases. Eight cases were selected to inject Gd-EOB-DTPA in dynamic contrast-enhanced MRI scan and Hepatocyte-specific scan, while 6 cases had spiral CT scan at the same time. 12 cases were inject Gd-DTPA MRI in dynamic contrast-enhanced scan, compare with the two contrast agent enhanced MRI and enhanced CT imaging characteristics. Results Eighty-three lesions were detected in 20 cases with MRI scan, 78 of which is found in the arterial phase, portal phase, and the balance phase. 55 lesions were found in the Hepatocyte-specific phase of 8 cases with injected Gd-EOB-DTPA, which 5 lesions in the dynamic phase (the conventional three scan) is not displayed. 6 cases with whole liver enhanced spiral CT scan revealed lesions in 31, contrast injection of Gd-EOB-DTPA enhanced MRI scans less found 8 lesions. Conclusion The hepatocyte-specific contrast agent Gd-EOB-DTPA in MRI dynamic enhancement is more conducive to the liver metastases detection and diagnosis.
, 百拇医药
[Key words] Hepatocyte-specific contrast agent; MRI; Metastasis;Liver
肝转移性肿瘤的早期诊断主要依赖于影像学检查，肝脏MR动态增强检查已经成为一种常用的临床诊断及鉴别诊断肝脏病变的有效方法，肝转移灶特别是<1.0 cm的转移灶的检出、分布和诊断对于临床诊断、治疗有着重要的意义。本文通过肝细胞特异性对比剂Gd-EOB-DTPA结合MRI动态增强对肝转移瘤全肝扫描进行分析诊断，旨在探讨肝细胞特异性对比剂在提高肝转移瘤MRI检出率和诊断率中的应用价值。
1 资料与方法
1.1 一般资料
收集我院2010年6月～2011年10月经临床、影像证实或高度怀疑的肝转移瘤20例患者行上腹部磁共振(MRI)检查。男14例，女6例，年龄41～65岁，平均年龄53岁。其中原发肿瘤为直结肠癌9例，胰腺癌4例，肺癌1例，胃癌4例，宫颈癌和乳腺癌各1例。合并肝囊肿3例，合并肝血管瘤2例。所有病例原发肿瘤均经临床及综合影像分析确诊或病理证实。其中6例患者(2例胃癌，2例结肠癌，1例胰腺癌，1例食管癌)在1个月内同时进行了静脉注射Gd-EOB-DTPA增强 MRI动态扫描和螺旋CT增强扫描。, 百拇医药(宣浩波 祝跃明 沈健 李凤琪 钱海峰)