贝复济在乳腺癌术后淋巴漏的应用(1)
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[摘要] 目的 探讨重组碱性成纤维细胞生长因子(贝复济，bFGF)在乳腺癌改良根治术后淋巴漏的治疗中的应用价值，以期为乳腺癌改良根治术后淋巴漏的治疗提供临床依据。 方法 将35例乳腺癌改良根治术后淋巴漏分为采用贝复济治疗的治疗组和采用滑石粉液治疗的对照组，比较两组患者的临床疗效。 结果 治疗组在第1天引流量、第2天引流量、第3天引流量和拔管天数等方面均少于对照组，差异有显著统计学意义(P < 0.01)，平均住院时间也明显短于对照组，差异有统计学意义(P < 0.05)。 结论 贝复济治疗乳腺癌改良根治术后淋巴漏具有良好的临床价值，值得推广和应用。
[关键词] 重组碱性成纤维细胞生长因子；乳腺癌；淋巴漏
[中图分类号] R737.9 [文献标识码] B [文章编号] 1673—9701(2012)24—0048—02
Application of bFGF in lymph leakage after breast carcinoma operation
YE Ping WANG Huangen
Department of Breast and Thyroid Surgery， the Central Hospital of Shaoxing County in Zhejiang Province， Shaoxing 312030， China
[Abstract] Objective To explore the applicational value of basic fibroblast growth factor (bFGF) in treatment of lymph leakage after breast carcinoma operation， and provide a new treatment method for lymph leakage after breast carcinoma operation. Methods Thirty—five patients of lymph leakage after breast carcinoma operation were divided into the use of bFGF treatment group and the talcum powder liquid treatment control group， compared two groups of patients with clinical efficacy. Results The treatment group were less than that in the control group with the first day drainage， the second day and third day drainage， extubation time， and there were significant differences (P < 0.01)， the average hospitalization time was significantly shorter than that in the control group， the difference was statistically significant (P < 0.05). Conclusion bFGF in lymph leakage after breast carcinoma operation has better clinical applicational value， and is worthy of wide application in clinic.
[Key words] Basic fibroblast growth factor； Breast cancer； Lymph leakage
乳腺癌是妇女最常见的恶性肿瘤之一，发病率仅次于宫颈癌，在世界范围内每年的新发病例超过120万。近年来随着我国社会经济的不断发展、生活方式的不断改变，乳腺癌的发病率逐年增加，已经成为危害我国妇女健康的主要恶性肿瘤，目前主要治疗手段是乳腺癌根治术，根治性手术因游离皮瓣及清扫腋窝淋巴结，术后易发生淋巴漏致皮下积液，并经久不愈，影响了皮瓣粘贴胸壁，从而造成皮瓣坏死，导致患者住院时间延迟，增加了患者的痛苦。为此我院采用贝复济治疗乳腺癌改良根治术后淋巴漏取得了良好的临床疗效 ......
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