LEEP治疗伴高危型HPV感染的宫颈上皮内瘤变患者应用探讨(1)
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[摘要] 目的 探讨宫颈环形电切术(LEEP)治疗伴高危型人乳头瘤病毒(HR—HPV)感染的宫颈上皮内瘤变(CIN)患者的应用价值。方法 回顾性分析2009年1月～2010年12月来我院妇科门诊经宫颈TCT诊断为ASCUS及以上的患者资料1 280例，其中对HR—HPV感染、阴道镜下多点活检组织病理学确诊为宫颈上皮内瘤变的患者329例行LEEP治疗，对术前HR—HPV亚型、术后HR—HPV转阴及CIN预后情况进行分析。结果 本组病例中HR—HPV阳性率52.19%，最常见的HR—HPV为16、58、52型。各HR—HPV阳性检出率术后6个月和术后12个月分别下降为32.22%和10.33%，与术前比较差异具有统计学意义(χ2=318.89，P < 0.01)。LEEP手术治疗HR—HPV感染的总有效率达72.34%。结论 LEEP治疗宫颈上皮内瘤变可以有效消除大部分HR—HPV感染，降低宫颈癌发生率。
[关键词] LEEP；HR—HPV；CIN
[中图分类号] R737.33 [文献标识码] B [文章编号] 1673—9701(2012)26—0146—03
Efficacy analysis of the LEEP treatment in cervical intraepithelial neoplasia patients with the high—risk type human papilloma virus infection
FAN Suhong YU Xiao XIA Lihua
Department of Gynecology， Affiliated Quzhou Central Hospital， Zhejiang University of Traditional Chinese Medicine， Quzhou 324000， China
[Abstract] Objective To discuss the efficacy of the loop electrosurgical excision procedure (LEEP) treatment in cervical intraepithelial neoplasia (CIN) patients with the high—risk type human papilloma virus (HR—HPV) infection. Methods The clinical data of 1 280 cases of gynecologic clinic patients diagnosed with ASCUS by cervical TCT from January 2009 to December 2010 were analyzed retrospectively. Among them， 329 cases of patients with HR—HPV infection and diagnosed with CIN by colposcopic multi—spot biopsy histopathology underwent routine LEEP treatment. The preoperative HR—HPV subtypes， postoperative negative turn and CIN prognosis were analyzed. Results The positive rate in this group was 52.19%， with HR—HPV types 16， 58， 52 being the most common. The HR—HPV positive rate was reduced to 32 ......
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