AFP、AFU、CA19—9和GGT在原发性肝癌诊断中的临床价值(1)
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[摘要] 目的 探讨甲胎蛋白(AFP)、α—L岩藻糖苷酶(AFU)、糖类抗原19—9(CA19—9)和γ—谷氨酰转肽酶(GGT)在原发性肝癌诊断中的临床价值。 方法 对我院就诊的30例原发性肝癌患者、40例肝炎、肝硬化、40例健康对照组血清AFP、AFU、CA19—9和GGT的浓度及阳性率进行检测，并对比分析。 结果 AFP、AFU、CA19—9和GGT在原发性肝癌的浓度均明显高于肝炎、肝硬化组及正常对照组(P < 0.01)。而AFP、AFU、CA19—9和GGT在肝炎、肝硬化组的浓度也明显高于正常对照组(P < 0.05)。AFP、AFU、CA19—9和GGT在原发性肝癌组织中的阳性率明显高于肝炎、肝硬化组的阳性率(P < 0.05)。但在正常组织中的阳性率均为0。且AFP、AFU、CA19—9和GGT四项指标联合检测阳性率明显高于任意指标单独检测的阳性率(P < 0.05)。AFP阳性率随着肿瘤组织的直径增大，其阳性率明显增加，其他未见明显差异。 结论 AFP、AFU、CA19—9和GGT联合检测可提高原发性肝癌诊断的阳性率，对原发性肝癌的早期诊断治疗和预后均有重要的临床应用价值。
[关键词] 原发性肝癌；AFP；AFU；CA19—9；GGT
[中图分类号] R735.7 [文献标识码] B [文章编号] 1673—9701(2012)27—0064—02
The clinical value of AFP， AFU，CA19—9 and GGT in the diagnosis of primary liver cancer
WANG Xinhua
Department of Clinical Laboratory，Taizhou Chinese and Western Medicine Hospital in Zheiiang Province，Taizhou 317523，China
[Abstract] Objective To explore the clinical value of alpha—fetoprotein(AFP)， α—L fucosidase (AFU，)， carbohydrate antigen 19—9 (CA19—9) and γ—glutamyl acyl transfer peptidase (GGT) in the diagnosis of primary liver cancer. Methods Selected 30 patients with primary liver cancer in our hospital， 40 cases of hepatitis， liver cirrhosis， 40 cases of healthy control group， and the serum of AFP， AFU， CA19—9 and the concentration and positive rate of GGT were compared and analyzed. Results AFP， AFU， CA19—9 concentration in primary liver cancer and GGT were significantly higher than those in hepatitis， liver cirrhosis group and the normal control group(P < 0.01). AFP， AFU， CA19—9 and GGT concentrations in the group of hepatitis， liver cirrhosis group were significantly higher than those in normal control group(P < 0.05). AFP， AFU， CA19—9， and GGT in primary hepatocellular carcinoma， the positive rate was significantly higher than that in hepatitis， cirrhosis of the group (P < 0.05). But the positive rate was 0 in normal tissue. And the positive rate of AFP， AFU， CA19—9 and GGT detected was significantly higher than that of the separate detection of any indicators(P < 0.05). With the increase of the tumor diameter， the positive rate of AFP increased significantly and the other was no significant difference. Conclusion AFP， AFU， CA19—9 and GGT joint detection can improve the positive rate of diagnosis of primary liver cancer. It has important clinical value of primary liver cancer early diagnosis and treatment and prognosis.
[Key words] Primary liver cancer；AFP；AFU；CA19—9；GGT
原发性肝癌(primary liver cancer，PHC)是我国常见的恶性肿瘤之一，具有恶性程度高、病情发展快、预后差、死亡率高等特点[1]，多数就诊时已属于中晚期，因此PHC的早期诊断和治疗对患者的预后具有重要意义。AFP、CA19—9、AFU、GGT是四种重要的消化系统肿瘤标志物，目前已经广泛应用于原发性肝癌的诊断中。本研究旨在探讨甲胎蛋白(AFP)、α—L岩藻糖苷酶(AFU)、糖类抗原19—9(CA19—9)和γ—谷氨酰转肽酶(GGT)在原发性肝癌诊断中的临床价值，现报道如下。
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