miR—124抑制胃癌MKN—45细胞的侵袭与转移(2)
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通过在线软件预测寻找miR-124作用的靶基因发现,miR-124的许多潜在靶基因如SPHK1、E-cadherin、CDK6等与肿瘤细胞增殖,粘附,迁移过程有关,miR-124可通过调控这些靶基因来发挥抑制胃癌细胞运动侵袭的功能。当然,尚有待于进一步的实验验证。阐明miR-124在胃癌发生发展中的作用对于认识胃癌发生的机制,探索新的有效的胃癌诊断预后评价标志物及治疗方法,具有重要的科学意义。
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(收稿日期:2012-11-15)
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