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CYP11B2基因第2内含子转位与醛固酮瘤发病的关系(2)
http://www.100md.com 2014年2月15日 邓西元
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    参见附件。

     所以,虽然CYP11B2基因intron 2转位是CYP11B2基因上常见突变,但是本研究发现其与APA患者血中高醛固酮无显著关联。

    [参考文献]

    [1] 邓西元,欧阳金芝,王保军,等. 11β羟化酶、醛固酮合成酶和类固醇合成因子基因在醛固酮瘤中的表达[J]. 中华实验外科杂志,2008,25(10):1350.

    [2] Takeda Y,Furukawa K,Inaba S,et al. Genetic analysis of aldosterone synthase in patients with idiopathic hyperald osteronism[J]. Clin Endocrinol Metab,1999,84(5):1633-1637.

    [3] Inglis GC,Plouin PF,Friel EC,et al. Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn’s syndrome)[J]. Clin Endocrinol(Oxf),2001,54(6):725-730.

    [4] Jerome N,David B,Lucas A,et al. A biallelic gene polymorphism of CYP11B2 predicts increased aldosterone to rennin ratio in selected hypertensive patients[J]. Clin Endocrinol Metab,2003,86(6):2495-2500.

    [5] 邓西元,张旭. 醛固酮瘤CYP11B2基因C-344T位点单核苷酸多态性与其发病关系[J]. 现代泌尿外科杂志,2010, 15(5):336-337,372.

    [6] Hautanena A,Lanlinen L,Kupari M,et al. Associations between aldosterone synthase gene polymorphism and the adrenocortical function in males[J]. J Intern Med,1998,244(1):11-18.

    [7] Tsujita Y,Iwai N,Katsuya T,et al. Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese: the suita study[J]. Hypertens Res,2001,24(2):105-109.

    (收稿日期:2013-11-18)

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