无创正压通气(BiPAP)治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的临床研究(1)
[摘要] 目的 观察无创正压通气(BiPAP)治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的临床治疗效果。 方法 选择2012年12月～2013年12月我院收治的慢性阻塞性肺病合并Ⅱ型呼吸衰竭64例，根据治疗方法不同分为观察组和对照组，每组各32例，对照组予常规治疗；观察组在对照组的基础上加用BiPAP无创呼吸机辅助通气治疗。比较两组患者治疗前、治疗后1 h、治疗后6 h、治疗后24 h、治疗后3 d的pH、PaO2、PaCO2的变化情况，及观察组出院后3个月、出院后6个月的症状评分、活动评分、影响评分及生活质量总分，并对两组的疗效进行比较。 结果治疗后1 h、治疗后6 h、治疗后24 h、治疗后3 d观察组和对照组患者的pH、PaO2、PaCO2均较治疗前显著改善，但治疗后1 h、治疗后6 h、治疗后24 h观察组的pH、PaO2、PaCO2较对照组变化更显著(P<0.05)。观察组的有效率达93.75%，显著高于对照组(P<0.05)。观察组出院后3个月、出院后6个月的症状评分、活动评分、影响评分及生活质量总分均较对照组改善更显著(P<0.05)。 结论 无创正压通气(BiPAP)治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭能显著提高疗效，提高氧分压、降低二氧化碳分压，从而提高患者的生活质量。
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[关键词] 无创正压通气(BiPAP)；慢性阻塞性肺疾病；合并；Ⅱ型呼吸衰竭；生活质量
[中图分类号] R563.9 [文献标识码] B [文章编号] 1673-9701(2015)09-0019-04
Clinical research of noninvasive positive pressure ventilation(BiPAP) in treatment of chronic obstructive pulmonary disease with type Ⅱ respiratory failure
LI Chengyu1 XIA Xiaodong2 FANG Yifeng1 CHEN Xinyi1
1.Department of Respiratory Medicine， the First People's Hospital of Yongkang City in Zhejiang Province， Yongkang 321300， China； 2.Department of Respiratory Medicine， the Second Hospital Affiliated to Wenzhou Medical College， Wenzhou 325000， China
, 百拇医药
[Abstract] Objective To observe the effect of noninvasive positive pressure ventilation (BiPAP) clinical curative effect in the treatment of chronic obstructive pulmonary disease with type Ⅱ respiratory failure. Methods From December 2012 to December 2013 in our hospital 64 cases patients with chronic obstructive pulmonary disease with type Ⅱ respiratory failure， according to the different treatment methods were divided into intervention group and control group， 32 cases in each group， the control group was treated with conventional treatment； the observation group was treated with non-invasive ventilation treatment with BiPAP. before treatment， after treatment 1 h， 6 h， 24 h， 3 d the pH， PaO2， PaCO2 changes were compared， after discharge 3， 6 months， the symptom score， activity score， score and the scores of quality of life influence， the efficacy of the two groups were compared. Results After treatment for 1 h， 6 h， 24 h， 3 d， pH， PaO2， PaCO2 of two groups were significantly improved than before， 1 h， 6 h，24 h after treatment， pH， PaO2， PaCO2 of observation group were improved significantly than the control group (P<0.05). The effective rate of the observation group was 93.75%， significantly higher than the control group (P<0.05). The activity scores and the scores of quality of life influence of observation group were improved more significantly than the control group (P<0.05). Conclusion Noninvasive positive pressure ventilation (BiPAP) in the treatment of chronic obstructive pulmonary disease combined with type Ⅱ respiratory failure can significantly improve the curative effect， improve the oxygen partial pressure， reduce the pressure of carbon dioxide， so as to improve the quality of life of the patients., 百拇医药(李成玉等)
, http://www.100md.com
[关键词] 无创正压通气(BiPAP)；慢性阻塞性肺疾病；合并；Ⅱ型呼吸衰竭；生活质量
[中图分类号] R563.9 [文献标识码] B [文章编号] 1673-9701(2015)09-0019-04
Clinical research of noninvasive positive pressure ventilation(BiPAP) in treatment of chronic obstructive pulmonary disease with type Ⅱ respiratory failure
LI Chengyu1 XIA Xiaodong2 FANG Yifeng1 CHEN Xinyi1
1.Department of Respiratory Medicine， the First People's Hospital of Yongkang City in Zhejiang Province， Yongkang 321300， China； 2.Department of Respiratory Medicine， the Second Hospital Affiliated to Wenzhou Medical College， Wenzhou 325000， China
, 百拇医药
[Abstract] Objective To observe the effect of noninvasive positive pressure ventilation (BiPAP) clinical curative effect in the treatment of chronic obstructive pulmonary disease with type Ⅱ respiratory failure. Methods From December 2012 to December 2013 in our hospital 64 cases patients with chronic obstructive pulmonary disease with type Ⅱ respiratory failure， according to the different treatment methods were divided into intervention group and control group， 32 cases in each group， the control group was treated with conventional treatment； the observation group was treated with non-invasive ventilation treatment with BiPAP. before treatment， after treatment 1 h， 6 h， 24 h， 3 d the pH， PaO2， PaCO2 changes were compared， after discharge 3， 6 months， the symptom score， activity score， score and the scores of quality of life influence， the efficacy of the two groups were compared. Results After treatment for 1 h， 6 h， 24 h， 3 d， pH， PaO2， PaCO2 of two groups were significantly improved than before， 1 h， 6 h，24 h after treatment， pH， PaO2， PaCO2 of observation group were improved significantly than the control group (P<0.05). The effective rate of the observation group was 93.75%， significantly higher than the control group (P<0.05). The activity scores and the scores of quality of life influence of observation group were improved more significantly than the control group (P<0.05). Conclusion Noninvasive positive pressure ventilation (BiPAP) in the treatment of chronic obstructive pulmonary disease combined with type Ⅱ respiratory failure can significantly improve the curative effect， improve the oxygen partial pressure， reduce the pressure of carbon dioxide， so as to improve the quality of life of the patients., 百拇医药(李成玉等)