[摘要] 目的 探讨麻醉方法及深度对胃癌患者围手术期细胞免疫功能的影响。 方法 选择60例胃癌手术患者为研究对象，随机分为静吸复合麻醉30例和单纯静脉麻醉30例，并根据患者的脑电双频指数分为深麻醉亚组和浅麻醉亚组。检测患者麻醉前、手术毕、手术后72 h外周血T细胞亚群和NK细胞数量。 结果 深麻醉亚组和浅麻醉亚组在手术毕时外周血CD3+、CD4+、CD4+/CD8+ T细胞数量以及NK细胞数量均显著低于麻醉前和术后72 h(P<0.05)。同一种麻醉方式下深麻醉亚组手术毕CD3+、CD4+、CD4+/CD8+ T细胞数量及NK细胞数量均显著高于浅麻醉亚组(P<0.05)。 结论 深麻醉对胃癌患者围手术期细胞免疫功能的影响较浅麻醉轻。

    [关键词] 麻醉方法；麻醉深度；胃癌手术；细胞免疫功能

    [中图分类号] R614 [文献标识码] B [文章编号] 1673-9701(2015)11-0125-03

    [Abstract] Objective To discuss effect of anesthesia methods and depth on perioperative cellular immune function of gastric cancer patients. Methods Sixty cases with gastric cancer treated by operation were randomly divided into inhalation anesthesia group and intravenous anesthesia group(each of 30 cases). Two groups were divided into deep anesthesia subgroup and light anesthesia subgroups according to BIS. T lymphocyte subsets and NK cell before anesthesia ......