瑞舒伐他汀联合普罗布考对脑梗死患者血脂、颈动脉粥样硬化斑块和hs—CRP的影响(1)
[摘要] 目的 探讨瑞舒伐他汀联合普罗布考对脑梗死患者颈动脉粥样硬化斑块的影响。 方法 选择脑梗死患者60例为研究对象，随机分为联合组和对照组各30例。联合组采用瑞舒伐他汀联合普罗布考治疗，对照组给予瑞舒伐他汀治疗。比较治疗前后两组患者颈动脉内膜厚度、斑块声学密度，检测两组患者治疗前后血脂、hs-CRP水平。结果 两组治疗后TC、TG、LDL-C、hs-CRP水平较治疗前均显著下降，而HDL-C水平显著升高，差异有高度统计学意义(P<0.01)。治疗后，联合组血脂水平改善程度、hs-CRP下降程度均显著优于对照组(P<0.01)。两组治疗后颈动脉IMT厚度较治疗前均显著下降(P<0.01)，联合组IMT厚度显著低于对照组；治疗后两组低回声斑块声学密度显著升高(P<0.01)；治疗后联合组高回声斑块声学密度显著升高(P<0.01)，而对照组变化不明显；治疗后，联合组低回声斑块、高回声斑块声学密度均显著高于对照组(P<0.01)。 结论 脑梗死患者给予瑞舒伐他汀联合普罗布考治疗，能够显著改善血脂水平，稳定颈动脉粥样硬化斑块，抑制炎症反应。
, http://www.100md.com
[关键词] 瑞舒伐他汀；普罗布考；脑梗死；颈动脉粥样硬化斑块
[中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701(2015)15-0064-03
[Abstract] Objective To discuss effect of rosuvastatin combined with probucol on carotid atherosclerotic plaque for infarction. Methods Selected 60 cases with infarction were randomly divided into joint group (30 cases) and control group (30 cases). Joint group was treated with rosuvastatin and probucol， and control group was treated with rosuvastatin. IMT， plaque acoustic densitometry of two groups were compared， and lipid and hs-CRP levels were detected before and after treatment. Results TC， TG， LDL-C， hs-CRP of two groups after treatment were lower than before treatment， while HDL-C was higher(P<0.01). After treatment， TC， TG， LDL-C， hs-CRP of joint group were lower than control group， and HDL-C was higher than that in the control group(P<0.01). IMT of two groups after treatment were lower than that in the before treatment(P<0.01) and IMT of joint group was lower than that in the control group； Low density acoustic echo plaques of two groups after treatment were higher than before treatment(P<0.01)； High density acoustic echo plaques of joint group after treatment was higher than before treatment(P<0.01) while the control group was not obviously； After treatment， acoustic echo plaques of jiont group were higher than control group(P<0.01). Conclusion Rosuvastatin associated with probucol for infarction patients can significantly improve blood lipid levels， stabilize carotid atherosclerotic plaque， and inhibit inflammation effect.
, 百拇医药
[Key words] Rosuvastatin； Probucol； Infarction； Carotid atherosclerotic plaque
颈动脉粥样硬化斑块脱落是导致脑梗死的主要原因，稳定颈动脉粥样硬化斑块对预防脑梗死具有重要的临床意义。血脂异常是动脉粥样硬化的独立高危因素。瑞舒伐他汀是一种选择性HMG-CoA还原酶抑制剂，降低VLDL和LDL微粒的总数，改善血脂水平，普罗布考具有调血脂和抗脂质过氧化作用[1，2]。两者均具有改善血脂水平的作用。本研究对脑梗死患者给予瑞舒伐他汀联合普罗布考治疗，评价其对患者颈动脉粥样硬化斑块的影响。现报道如下。
1资料与方法
1.1一般资料
选择2013年1月～2014年6月在我院治疗的脑梗死患者60例为研究对象。纳入标准：①符合脑梗死的诊断标准，头颅影像学证实为脑梗死，排除脑出血、TIA发作、蛛网膜下腔出血；②首次发病，既往无脑卒中病史；③入组时距离发病1周内；④均伴有高脂血症。排除标准：①年龄≥80岁，合并其他系统严重疾病；②对所使用的药物过敏；③恶性肿瘤、急性炎症、免疫系统疾病、使用免疫抑制剂者；④服用避孕药、激素类药物的女性；⑤孕期或哺乳期女性；⑥心源性脑栓塞。60例患者随机分为联合组和对照组各30例。联合组男16例，女14例，平均年龄(60.6±7.1)岁；对照组男13例，女17例，平均年龄(61.3±7.9)岁。两组患者的性别比、平均年龄比较差异无统计学意义(P>0.05)。, 百拇医药(许宏侠)
, http://www.100md.com
[关键词] 瑞舒伐他汀；普罗布考；脑梗死；颈动脉粥样硬化斑块
[中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701(2015)15-0064-03
[Abstract] Objective To discuss effect of rosuvastatin combined with probucol on carotid atherosclerotic plaque for infarction. Methods Selected 60 cases with infarction were randomly divided into joint group (30 cases) and control group (30 cases). Joint group was treated with rosuvastatin and probucol， and control group was treated with rosuvastatin. IMT， plaque acoustic densitometry of two groups were compared， and lipid and hs-CRP levels were detected before and after treatment. Results TC， TG， LDL-C， hs-CRP of two groups after treatment were lower than before treatment， while HDL-C was higher(P<0.01). After treatment， TC， TG， LDL-C， hs-CRP of joint group were lower than control group， and HDL-C was higher than that in the control group(P<0.01). IMT of two groups after treatment were lower than that in the before treatment(P<0.01) and IMT of joint group was lower than that in the control group； Low density acoustic echo plaques of two groups after treatment were higher than before treatment(P<0.01)； High density acoustic echo plaques of joint group after treatment was higher than before treatment(P<0.01) while the control group was not obviously； After treatment， acoustic echo plaques of jiont group were higher than control group(P<0.01). Conclusion Rosuvastatin associated with probucol for infarction patients can significantly improve blood lipid levels， stabilize carotid atherosclerotic plaque， and inhibit inflammation effect.
, 百拇医药
[Key words] Rosuvastatin； Probucol； Infarction； Carotid atherosclerotic plaque
颈动脉粥样硬化斑块脱落是导致脑梗死的主要原因，稳定颈动脉粥样硬化斑块对预防脑梗死具有重要的临床意义。血脂异常是动脉粥样硬化的独立高危因素。瑞舒伐他汀是一种选择性HMG-CoA还原酶抑制剂，降低VLDL和LDL微粒的总数，改善血脂水平，普罗布考具有调血脂和抗脂质过氧化作用[1，2]。两者均具有改善血脂水平的作用。本研究对脑梗死患者给予瑞舒伐他汀联合普罗布考治疗，评价其对患者颈动脉粥样硬化斑块的影响。现报道如下。
1资料与方法
1.1一般资料
选择2013年1月～2014年6月在我院治疗的脑梗死患者60例为研究对象。纳入标准：①符合脑梗死的诊断标准，头颅影像学证实为脑梗死，排除脑出血、TIA发作、蛛网膜下腔出血；②首次发病，既往无脑卒中病史；③入组时距离发病1周内；④均伴有高脂血症。排除标准：①年龄≥80岁，合并其他系统严重疾病；②对所使用的药物过敏；③恶性肿瘤、急性炎症、免疫系统疾病、使用免疫抑制剂者；④服用避孕药、激素类药物的女性；⑤孕期或哺乳期女性；⑥心源性脑栓塞。60例患者随机分为联合组和对照组各30例。联合组男16例，女14例，平均年龄(60.6±7.1)岁；对照组男13例，女17例，平均年龄(61.3±7.9)岁。两组患者的性别比、平均年龄比较差异无统计学意义(P>0.05)。, 百拇医药(许宏侠)