[摘要] 目的 研究应用微电极辅助定位立体定向手术治疗帕金森病的手术技巧、临床效果及并发症的防治。 方法 对456例帕金森病患者行微电极辅助立体定向毁损手术治疗，总结手术技巧，并就术后症状改善情况及并发症进行分析。 结果 近期总有效率达97.59%，无严重及永久性并发症。 结论 立体定向手术是治疗帕金森病安全和有效的方法，靶点的精确定位及注意手术技巧是提高手术疗效、减少并发症的关键。

    [关键词] 帕金森病；微电极记录；立体定向；手术治疗

    [中图分类号] R742.5 [文献标识码] B [文章编号] 1673-9701(2015)16-0027-03

    [Abstract] Objective To study the surgical skills， clinical effects and complications prevention of microelectrode assisted stereotactic surgery in treatment of Parkinson's disease. Methods A total of 456 cases of patients with Parkinson's disease were treated with microelectrode assisted stereotactic surgery. Surgical skills were summarized and postoperative symptoms improvement and complications were analyzed. Results The recent total effective rate was 97.59% without serious or permanent complications. Conclusion Stereotactic surgery is a safe and effective treatment of Parkinson's disease. The precise positioning of target and surgical shills are keys to improving surgical outcome and reducing complications. ......