牙周干预对2型糖尿病患者脂联素浓度、C—反应蛋白和胰岛素抵抗指数的影响(1)
[摘要] 目的 探讨牙周干预对2型糖尿病患者的C-反应蛋白(CRP)、脂联素(APN)浓度、胰岛素抵抗指数(HOMA-IR)的影响。 方法 选择2013年12月～2014年11月间126例伴糖尿病牙周炎患者，根据是否进行牙周干预将其随机分为观察组(n=63)接受牙周干预治疗和对照组(n=63)不接受牙周干预治疗。比较两组患者治疗前后的FPG、HbA1c、CRP、APN、FINS，计算HOMA-IR。 结果 两组患者治疗前上述指标比较差异无统计学意义(P>0.05)，治疗2个月后，两组患者APN 较治疗前升高(P<0.05)，CRP、HOMA-IR均较治疗前下降(P<0.05)，空腹血糖和随机血糖均有改善，且观察组改善程度明显高于对照组(P<0.05)。 结论 牙周干预对2型糖尿病患者的脂联素浓度、C-反应蛋白和胰岛素抵抗具有改善作用。
[关键词] 牙周干预；脂联素；2型糖尿病；胰岛素抵抗；C-反应蛋白；血糖
[中图分类号] R781.4 [文献标识码] B [文章编号] 1673-9701(2015)23-0067-03
, 百拇医药
The impact on CRP， APN， HOMA-IR of periodontal intervention for patients with type-2 diabetes
XU Hao PAN Jian GU Haoyong
Department of Dentistry， Zhenhai Longsai Dental Hospital of Ningbo City， Ningbo 315200， China
[Abstract] Objective To investigate the impact on adiponectin (APN) concentration， C-reactive protein (CRP)， insulin resistance index(HOMA-IR) in patients with type 2 diabetes by periodontal intervention. Methods All 126 patients with diabetic were selected from December 2013 to November 2014， and they were randomly divided into observation group (n=63) and control group(n=63)， trail paitents were treated with periodontal intervention， and control group were not treated with periodontal intervention. The FPG， HbA1c， CRP， APN， FINS， HOMA-IR of the two groups before and after treatment were compared. Results The serum APN， CRP， HOMA-IR of two groups of patients before treatment， the difference was not statistically significant difference(P>0.05)； After two months of treatment， APN levels of both groups of patients were increased compared with before treatment， the CRP， HOMA-IR levels were decreased compared with before treatment， the differences were statistically significant(P<0.05)； After treatment， APN， CRP， HOMA-IR levels improved more significantly， the difference was statistically significant(P<0.05). After treatment， fasting and random blood glucose were improved， but the improvement of the patients in the observation group was better than the control group of patients， the difference was statistically significant(P<0.05). Conclusion Periodontal intervention play an important role in type 2 diabetes adiponectin genotype different C- reactive protein and insulin resistance improvemen
研究发现，牙周炎和糖尿病存在双向关系，两者之间存在共同发病危险因素，并且互为高危因素[1，2]。糖尿病会增加牙周炎的发病风险及严重程度，是牙周炎发生和发展的重要危险因素。同时，牙周炎也是糖尿病发生发展的高危因素，并能增加发生糖尿病并发症如糖尿病肾病和心血管疾病等的风险，有效的牙周治疗利于血糖控制。胰岛P细胞功能减退和胰岛素抵抗(insulinresistance，IR)是两个引起糖尿病发病的关键因素，而炎症在该过程中起到重要和关键作用。低脂联素血症和高C-反应蛋白被认为与2型糖尿病发展过程中的IR和高胰岛素血症有关[3，4]。本文即对牙周干预调控对2型糖尿病患者的C-反应蛋白、脂联素浓度、胰岛素抵抗指数的影响进行研究，旨在探讨糖尿病患者牙周炎防治的机制和意义，从而提高临床对糖尿病的认识，现报道如下。, 百拇医药(徐浩 潘建 顾豪勇)
[关键词] 牙周干预；脂联素；2型糖尿病；胰岛素抵抗；C-反应蛋白；血糖
[中图分类号] R781.4 [文献标识码] B [文章编号] 1673-9701(2015)23-0067-03
, 百拇医药
The impact on CRP， APN， HOMA-IR of periodontal intervention for patients with type-2 diabetes
XU Hao PAN Jian GU Haoyong
Department of Dentistry， Zhenhai Longsai Dental Hospital of Ningbo City， Ningbo 315200， China
[Abstract] Objective To investigate the impact on adiponectin (APN) concentration， C-reactive protein (CRP)， insulin resistance index(HOMA-IR) in patients with type 2 diabetes by periodontal intervention. Methods All 126 patients with diabetic were selected from December 2013 to November 2014， and they were randomly divided into observation group (n=63) and control group(n=63)， trail paitents were treated with periodontal intervention， and control group were not treated with periodontal intervention. The FPG， HbA1c， CRP， APN， FINS， HOMA-IR of the two groups before and after treatment were compared. Results The serum APN， CRP， HOMA-IR of two groups of patients before treatment， the difference was not statistically significant difference(P>0.05)； After two months of treatment， APN levels of both groups of patients were increased compared with before treatment， the CRP， HOMA-IR levels were decreased compared with before treatment， the differences were statistically significant(P<0.05)； After treatment， APN， CRP， HOMA-IR levels improved more significantly， the difference was statistically significant(P<0.05). After treatment， fasting and random blood glucose were improved， but the improvement of the patients in the observation group was better than the control group of patients， the difference was statistically significant(P<0.05). Conclusion Periodontal intervention play an important role in type 2 diabetes adiponectin genotype different C- reactive protein and insulin resistance improvemen
研究发现，牙周炎和糖尿病存在双向关系，两者之间存在共同发病危险因素，并且互为高危因素[1，2]。糖尿病会增加牙周炎的发病风险及严重程度，是牙周炎发生和发展的重要危险因素。同时，牙周炎也是糖尿病发生发展的高危因素，并能增加发生糖尿病并发症如糖尿病肾病和心血管疾病等的风险，有效的牙周治疗利于血糖控制。胰岛P细胞功能减退和胰岛素抵抗(insulinresistance，IR)是两个引起糖尿病发病的关键因素，而炎症在该过程中起到重要和关键作用。低脂联素血症和高C-反应蛋白被认为与2型糖尿病发展过程中的IR和高胰岛素血症有关[3，4]。本文即对牙周干预调控对2型糖尿病患者的C-反应蛋白、脂联素浓度、胰岛素抵抗指数的影响进行研究，旨在探讨糖尿病患者牙周炎防治的机制和意义，从而提高临床对糖尿病的认识，现报道如下。, 百拇医药(徐浩 潘建 顾豪勇)