[摘要] 目的 探讨上皮间质转化(epithelial-mesenchymal transition，EMT)对宫颈癌侵袭和转移的影响。 方法 对33例宫颈浸润癌组织和23例宫颈原位癌组织(对照组)采用免疫组化方法进行EMT标志物的检测。 结果 ①免疫组化检测显示56例宫颈癌组织中，发生浸润及淋巴结转移后，E-cadherin/β-catenin复合物的表达显著低于原位癌组织(P<0.05)，而Vimentin的表达显著高于原位癌组织(P<0.05)。②浸润性宫颈癌组织中Fibronectin及N-cadherin表达与组织学分级密切相关。③FN的表达与癌组织的浸润深度相关。 结论 宫颈癌的侵袭转移过程中存在着EMT现象，可以为宫颈癌的靶向治疗提供理论依据。

    [关键词] EMT；宫颈癌；转移；免疫组化

    [中图分类号] R737.3 [文献标识码] A [文章编号] 1673-9701(2016)09-0005-04

    [Abstract] Objective To investigate the effect of EMT on the invasion and metastasis of cervical cancer. Methods Immunohistochemistry was use to detectded the expression of markers of EMT in 33 cases of invasive cervical cancer and 23 cases of cervical carcinoma in situ (control group). Results ①Expression of E-cadherin/β-catenin in invasive carcinoma and lymph node metastasis group was lower than carcinoma in situ(P<0.05) ......