综上所述，冠状动脉侧支循环主要出现在严重冠心病中，且冠状动脉病变的严重程度和IL-8以及PF4均是造成侧支循环生成的重要因素。

    [参考文献]

    [1] Woo Jin Jang，Young Bin Song，JooYong Hahn，et al.Long-term survival benefit of revascularization compared with medical therapy in patients with coronary chronic total occlusion and well-developed collateral circulation[J]. Journal of the American College of Cardiology，2014，127(17)：3077-3081.

    [2] Liu XW，Aijun Sun，Jun Re，et al. Mitochondrial aldehyde dehydrogenase 2(ALDH2) regulates revascularization in chronic ischemia：Significant for the development of the coronary artery collateral circulation[J]. Journal of the American College of Cardiology ......