右美托咪定对全麻下腹腔手术患者的辅助性麻醉效果评价(1)
[摘要] 目的 探讨右美托咪定对全麻下腹腔手术患者的辅助性麻醉效果，并为手术的顺利实施提供科学依据。方法 选取研究对象为2013年11月～2014年11月期间我院行全麻腹腔手术100例患者，回顾性分析其临床病历资料。根据麻醉方式的不同将其分为实验组(52例)和对照组(48例)，实验组患者于麻醉诱导前注射右美托咪定，而对照组患者用生理盐水替代，其余处理方式相同。观察两组患者的麻醉效果并进行比较。 结果 用药后10 min，实验组患者镇静评分(RSS)明显高于对照组患者[(4.4±0.5) vs (2.8±0.4)]，差异有统计学意义(P<0.05)；在麻醉诱导过程中，实验组患者丙泊酚使用量明显低于对照组[(90.6±3.5)mg vs (124.5±4.6)mg]，差异有统计学意义(P<0.05)，而两组患者不良反应发生率差异无统计学意义(P>0.05)；在手术结束时，实验组患者平均动脉压明显低于对照组[(81.3±2.6)mmHg vs(102.4±3.6)mmHg]，同时实验组患者心率也显著低于对照组[(66.6±3.8)bmp vs(88.3±4.9)bmp]，差异有统计学意义(P<0.05)。 结论 对全麻下腹腔手术患者于麻醉诱导前给予注射右美托咪定有利于加强患者镇静深度，减少麻醉诱导过程中丙泊酚的使用量，并有利于患者术后血压以及心率的稳定。因此，该方法应该在临床上进一步推广和使用。
[关键词] 右美托咪定；全麻；腹腔手术；麻醉效果
[中图分类号] R614 [文献标识码] B [文章编号] 1673-9701(2016)10-0114-04
[Abstract] Objective To evaluate the assisted anesthetic effect of dexmedetomidine on patients with abdominal operation under general anesthesia， so as to supply scientific evidence of successful operation. Methods From November 2013 to November 2014， 100 cases of patients with abdominal operation under general anesthesia were prospectively studied. According to different styles of anesthetic， the patients were divided into two groups， experimental group and control group. In experimental group， 52 cases were treated with dexmedetomidine before anesthesia induction， while 48 cases in the control group were treated with physiological saline for replacement. The anesthetic effect of the two groups were observed and compared. Results After treatment 10 min， the RSS score of the experimental group was significantly higher than that of the control group[(4.4±0.5) vs (2.8±0.4)]，the difference was statitically significant(P<0.05). During the process anesthetic， the amount of propofol usage in the experimental group was significantly lower than that in the control group[(90.6±3.5)mg vs(124.5±4.6)mg]， the difference was statitically significant(P<0.05)， but there was no difference about the ratio of compliance in these two groups(P>0.05). After operation， the MAP and HR in the observation group was significantly lower than that in the control group with [(81.3±2.6)mmHg vs(102.4±3.6)mmHg]and [(66.6±3.8)bmp vs(88.3±4.9)bmp] respectively， the difference was statitically significant(P<0.05). Conclusion The dexmedetomidine is used in the patients with abdominal operation under general anesthesia， which strengthen the depth of sedation of patients. Moreover it also reduces the usage of propofol during induction of anesthesia， with being beneficial to the patients’ blood pressure and heart rate stability. Therefore， this method should be further popularized and used in clinic., http://www.100md.com(曹东航 陈斌 胡国强)
[关键词] 右美托咪定；全麻；腹腔手术；麻醉效果
[中图分类号] R614 [文献标识码] B [文章编号] 1673-9701(2016)10-0114-04
[Abstract] Objective To evaluate the assisted anesthetic effect of dexmedetomidine on patients with abdominal operation under general anesthesia， so as to supply scientific evidence of successful operation. Methods From November 2013 to November 2014， 100 cases of patients with abdominal operation under general anesthesia were prospectively studied. According to different styles of anesthetic， the patients were divided into two groups， experimental group and control group. In experimental group， 52 cases were treated with dexmedetomidine before anesthesia induction， while 48 cases in the control group were treated with physiological saline for replacement. The anesthetic effect of the two groups were observed and compared. Results After treatment 10 min， the RSS score of the experimental group was significantly higher than that of the control group[(4.4±0.5) vs (2.8±0.4)]，the difference was statitically significant(P<0.05). During the process anesthetic， the amount of propofol usage in the experimental group was significantly lower than that in the control group[(90.6±3.5)mg vs(124.5±4.6)mg]， the difference was statitically significant(P<0.05)， but there was no difference about the ratio of compliance in these two groups(P>0.05). After operation， the MAP and HR in the observation group was significantly lower than that in the control group with [(81.3±2.6)mmHg vs(102.4±3.6)mmHg]and [(66.6±3.8)bmp vs(88.3±4.9)bmp] respectively， the difference was statitically significant(P<0.05). Conclusion The dexmedetomidine is used in the patients with abdominal operation under general anesthesia， which strengthen the depth of sedation of patients. Moreover it also reduces the usage of propofol during induction of anesthesia， with being beneficial to the patients’ blood pressure and heart rate stability. Therefore， this method should be further popularized and used in clinic., http://www.100md.com(曹东航 陈斌 胡国强)