脑心通胶囊联合强力定眩胶囊及阿托伐他汀钙片对颈动脉粥样硬化斑块影响的临床观察(1)
[摘要] 目的 探讨脑心通胶囊联合强力定眩胶囊及阿托伐他汀钙片对颈动脉粥样硬化斑块的影响。 方法 回顾性分析2013年10月～2015年11月我院接诊的60例颈动脉粥样硬化患者的临床资料，通过随机数表法分为治疗组(30例)和对照组(30例)，对照组给予阿托伐他汀钙片治疗，治疗组在对照组的基础上加用脑心通胶囊及强力定眩胶囊。比较两组患者治疗前后颈动脉硬化斑块数量、IMT、斑块的面积、血脂(TC、TG、LDL-C)、hs-CRP水平的变化情况，并比较治疗过程中所出现的不良反应。 结果 治疗组颈动脉斑块数量、面积、IMT水平均比对照组低[(1.24±0.31) vs (1.57±0.37)，(16.17±2.05)mm2 vs (33.41±5.84)mm2，(1.48±0.35)mm vs (1.74±0.54)mm](P<0.05)；TC、TG、LDL-C、hs-CRP水平也低于对照组[(3.81±0.67)mmol/L vs (4.32±0.80)mmol/L，(1.28±0.22)mmol/L vs (1.54±0.38)mmol/L，(2.07±0.50)mmol/L vs (2.41±0.48)mmol/L，(2.53±0.36)mg/L vs (4.23±0.94)mg/L](P<0.05)。 结论 脑心通胶囊联合强力定眩胶囊及阿托伐他汀钙片在颈动脉粥样硬化斑块患者中疗效显著，值得应用推广。
[关键词] 脑心通胶囊；强力定眩胶囊；阿托伐他汀钙片；颈动脉粥样硬化斑块；斑块数量；血脂
[中图分类号] R543.4 [文献标识码] A [文章编号] 1673-9701(2016)15-0015-04
[Abstract] Objective To investigate the effect of Naoxintong capsule combined with strong glare capsule and on carotid atherosclerosis. Methods A total of 60 cases of patients with carotid atherosclerosis from October 2013 to November 2015 in our hospital， were divided into observation group(30 cases) and control group(30 cases) by randomly. The control group was given atorvastatin calcium tablets treatment， in the observation group， the observation group with Naoxintong capsule and Qiangli Dingxuan capsule. They were compared with carotid atherosclerotic plaque， IMT， area，blood lipids(TC， TG， LDL-C)， hs-CRP levels of change before and after treatment， and compared the adverse reactions in the treatment process. Results The carotid plaque number， area and IMT in the observation group were lower than that in the control group[(1.24±0.31)vs(1.57±0.37)，(16.17±2.05)mm2 vs(33.41±5.84)mm2，(1.48±0.35)mm vs(1.74±0.54)mm](P<0.05)； the levels of TC， TG， LDL-C and hs-CRP were also lower than those in the control group [(3.81±0.67)mmol/L vs (4.32±0.80)mmol/L，(1.28±0.22)mmol/L vs (1.54±0.38)mmol/L，(2.07±0.50)mmol/L vs(2.41±0.48)mmol/L，(2.53±0.36)mg/L vs(4.23±0.94)mg/L](P<0.05). Conclusion Naoxintong capsule， Qiangli Dingxuan capsule and atorvastatin in patients with carotid atherosclerosis plaque effect is significant， worthy of promotion and application.
[Key words] Naoxintong capsules； Qiangli Dingxuan capsule； Atorvastatin； Carotid atherosclerotic plaques； Plaque quantity； Blood lipid
在缺血性脑卒中之中，颈动脉粥样硬化是独立的危险因素，并且缺血性脑卒中有着反复发作的特点，与颈动脉粥样硬化存在着紧密的关系，在临床上，对此类患者的研究重点主要是如何稳定、减少、消退斑块为目的[1，2]。在颈动脉粥样硬化患者中，阿托伐他汀钙片在临床上是十分常用的药物，该药具有抗氧化、抗炎、调脂的良好疗效[3]。脑心通胶囊在临床上的主要作用为活血化瘀、通脉，并具有抗凝、抗血栓之效[4，5]。强力定眩胶囊在临床上的疗效主要有降压、降脂、定眩，在高血压、动脉硬化患者均有着广泛应用[6]。此次我院在颈动脉粥样硬化患者中进行脑心通胶囊、强力定眩胶囊以及阿托伐他汀钙的联合应用，取得的效果优异，现报道如下。, 百拇医药(朱雪琼 林希 林祥)
[关键词] 脑心通胶囊；强力定眩胶囊；阿托伐他汀钙片；颈动脉粥样硬化斑块；斑块数量；血脂
[中图分类号] R543.4 [文献标识码] A [文章编号] 1673-9701(2016)15-0015-04
[Abstract] Objective To investigate the effect of Naoxintong capsule combined with strong glare capsule and on carotid atherosclerosis. Methods A total of 60 cases of patients with carotid atherosclerosis from October 2013 to November 2015 in our hospital， were divided into observation group(30 cases) and control group(30 cases) by randomly. The control group was given atorvastatin calcium tablets treatment， in the observation group， the observation group with Naoxintong capsule and Qiangli Dingxuan capsule. They were compared with carotid atherosclerotic plaque， IMT， area，blood lipids(TC， TG， LDL-C)， hs-CRP levels of change before and after treatment， and compared the adverse reactions in the treatment process. Results The carotid plaque number， area and IMT in the observation group were lower than that in the control group[(1.24±0.31)vs(1.57±0.37)，(16.17±2.05)mm2 vs(33.41±5.84)mm2，(1.48±0.35)mm vs(1.74±0.54)mm](P<0.05)； the levels of TC， TG， LDL-C and hs-CRP were also lower than those in the control group [(3.81±0.67)mmol/L vs (4.32±0.80)mmol/L，(1.28±0.22)mmol/L vs (1.54±0.38)mmol/L，(2.07±0.50)mmol/L vs(2.41±0.48)mmol/L，(2.53±0.36)mg/L vs(4.23±0.94)mg/L](P<0.05). Conclusion Naoxintong capsule， Qiangli Dingxuan capsule and atorvastatin in patients with carotid atherosclerosis plaque effect is significant， worthy of promotion and application.
[Key words] Naoxintong capsules； Qiangli Dingxuan capsule； Atorvastatin； Carotid atherosclerotic plaques； Plaque quantity； Blood lipid
在缺血性脑卒中之中，颈动脉粥样硬化是独立的危险因素，并且缺血性脑卒中有着反复发作的特点，与颈动脉粥样硬化存在着紧密的关系，在临床上，对此类患者的研究重点主要是如何稳定、减少、消退斑块为目的[1，2]。在颈动脉粥样硬化患者中，阿托伐他汀钙片在临床上是十分常用的药物，该药具有抗氧化、抗炎、调脂的良好疗效[3]。脑心通胶囊在临床上的主要作用为活血化瘀、通脉，并具有抗凝、抗血栓之效[4，5]。强力定眩胶囊在临床上的疗效主要有降压、降脂、定眩，在高血压、动脉硬化患者均有着广泛应用[6]。此次我院在颈动脉粥样硬化患者中进行脑心通胶囊、强力定眩胶囊以及阿托伐他汀钙的联合应用，取得的效果优异，现报道如下。, 百拇医药(朱雪琼 林希 林祥)