[摘要] 目的 观察冠心病心力衰竭患者联合应用曲美他嗪与辛伐他汀对血浆BNP的影响及临床效果分析。 方法 选取我院心内科2013 年1 月～2015 年8月收治的120例确诊为冠心性心力衰竭患者作为研究对象，随机将患者均分为治疗组与对照组，对照组(辛伐他汀治疗)、治疗组(曲美他嗪+辛伐他汀治疗)各60例。观察临床疗效和不良反应，比较血浆BNP与心功能变化。 结果 治疗组治疗有效率为96.7%，高于对照组的85.0%；治疗后血浆BNP、血压、心率、LVEDD、LVESD均降低，LVEF升高，且治疗组改善更明显，差异有统计学意义(P<0.05)。 结论 联合应用曲美他嗪与辛伐他汀能明显降低冠心病导致的心力衰竭患者BNP 的含量，显著改善冠心病心力衰竭的心功能状况。

    [关键字] 冠心病；心力衰竭；曲美他嗪；辛伐他汀；心功能；BNP

    [中图分类号] R541.6 [文献标识码] B [文章编号] 1673-9701(2016)16-0101-03

    [Abstract] Objective To observe the effects of the combined application of trimetazidine and simvastatin on plasma BNP in the patients with coronary heart disease complicated with heart failure and analyze the clinical curative effects. Methods 120 patients who were diagnosed of coronary heart disease complicated with heart failure and admitted to the Department of Internal Medicine in our hospital from January 2013 to August 2015 were selected as the research subjects. The patients were randomly and evenly assigned to the treatment group and the control group ......