茶春丽 陈国姝 李靖娟 代留玲 李 俊

    昆明医科大学第一附属医院肾内科，云南昆明650032

    慢性肾脏疾病患者血清锌离子的变化及临床意义

    茶春丽陈国姝李靖娟代留玲李俊▲

    昆明医科大学第一附属医院肾内科，云南昆明650032

    目的探讨慢性肾脏病患者血清锌离子的变化情况及临床意义。方法选择2015年9～12月在本院收治的慢性肾脏疾病101例患者，并选择同期我院健康体检患者18例作为正常对照组，测定血清锌离子水平和常规生化测定肾功能、总蛋白、白蛋白等，并进行卡方检验、方差分析及Pearson相关性分析。结果与正常对照组比较，CKD各期血锌降低，差异有统计学意义(P<0.05)；与CKD 1期相比，CKD 2～5期血锌降低，差异有统计学意义(P<0.05)；相关分析结果提示，血清锌离子与血磷水平呈显著负相关，与血清总蛋白、白蛋白和血钙水平呈正相关。结论CKD患者体内血清锌离子水平降低，且与血磷、血清总蛋白、白蛋白和血钙有相关性，血锌降低可能与蛋白、血钙丢失、血磷沉积有关；纠正慢性肾脏病患者低血锌水平，有助于预防其并发症的发生。

    慢性肾脏病；锌；低锌血症；微量元素

    [Abstract]Objective To discuss the changes and clinical significance of serum zinc ions in chronic kidney diseases(CKD).Methods A total of 101 CKD patients treated in our hospital from September to December 2015 were selected and another 18 healthy volunteer were enrolled into the control group.The level of serum zinc ions and routine biochemical parameters including renal function，total protein，and albumin were detected.The results were analyzed by chi-square test，variance analysis，and Pearson correlation analysis.Results Compared with the control group，the level of serum zinc ions was significantly lower in CKD patients at various stages(P<0.05).Compared with CKD patients at stage 1 ......